Renal iron deposition by magnetic resonance imaging in pediatric β-thalassemia major patients: Relation to renal biomarkers, total body iron and chelation therapy

•Kidney iron deposition impairs renal glomerular and tubular functions in β-TM.•Renal R2*was higher in patients with poor compliance to chelation therapy.•Renal T2* cutoff

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Bibliographic Details
Published in:European journal of radiology 2018-06, Vol.103, p.65-70
Main Authors: ElAlfy, Mohsen Saleh, Khalil Elsherif, Nayera Hazaa, Ebeid, Fatma Soliman Elsayed, Ismail, Eman Abdel Rahman, Ahmed, Khaled Aboulfotouh, Darwish, Yasser Wagih, Ibrahim, Ahmed Samir, Elghamry, Islam Reda Farag, Shokrey, Nermeen Adel, Alajeil, Dunia Naser
Format: Article
Language:English
Subjects:
beta-Thalassemia - diagnostic imaging
beta-Thalassemia - metabolism
Biomarkers - metabolism
Chelation Therapy - methods
Child
Cross-Sectional Studies
Cystatin C
Female
Humans
Iron - metabolism
Iron Overload - diagnostic imaging
Iron Overload - metabolism
Iron Overload - therapy
Liver - diagnostic imaging
Liver - metabolism
Magnetic Resonance Imaging - methods
Male
Renal R2
Tissue iron overload
β-Thalassemia major
β2-Microglobulin
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Description
Summary:•Kidney iron deposition impairs renal glomerular and tubular functions in β-TM.•Renal R2*was higher in patients with poor compliance to chelation therapy.•Renal T2* cutoff
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2018.04.007