Intervention of curcumin on oral pharmacokinetics of daclatasvir in rat: A possible risk for long‐term use

Curcumin, a natural diarylheptanoid, is extensively used as a food additive or dietary supplement on the regular basis. It is known to have potential to encumber the drug transporters and hepatic drug metabolizing enzymes that lead to pharmacokinetic interactions with drug or food. Daclatasvir is a...

Full description

Saved in:
Bibliographic Details
Published in:Phytotherapy research 2018-10, Vol.32 (10), p.1967-1974
Main Authors: Dogra, Ashish, Bhatt, Shipra, Magotra, Asmita, Sharma, Anjna, Kotwal, Pankul, Gour, Abhishek, Wazir, Priya, Singh, Gurdarshan, Nandi, Utpal
Format: Article
Language:English
Subjects:
Antiviral drugs
Curcumin
daclatasvir
Diet
Dietary supplements
Drug dosages
Food additives
food–drug interaction
Glycoproteins
Hepatitis
Hepatitis C
herb–drug interaction
Ketoconazole
Oral administration
Pharmacokinetics
Pharmacology
Quinidine
Substrates
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Curcumin, a natural diarylheptanoid, is extensively used as a food additive or dietary supplement on the regular basis. It is known to have potential to encumber the drug transporters and hepatic drug metabolizing enzymes that lead to pharmacokinetic interactions with drug or food. Daclatasvir is a new orally acting drug for the treatment of chronic Hepatitis C Virus infections. This is a substrate of P‐glycoprotein and CYP3A4 that are involved in the major pharmacokinetic interaction. Hence, the studies' aim is to assess for any possible pharmacokinetic interactions. Pharmacokinetic studies of daclatasvir in presence or absence of curcumin were carried out in Wistar rats following oral administration. Parallelly, the oral pharmacokinetics of daclatasvir was also determined in the presence of ketoconazole or quinidine. Studies revealed that plasma level of daclatasvir was not altered significantly during concomitant single dose administration of curcumin, whereas significantly decreased upon pretreatment for 7 days with curcumin at high dose level. Ketoconazole and quinidine markedly increase daclatasvir exposure following concomitant administration with daclatasvir. It can be concluded that dose adjustment is unlikely to be required for intermittent use of curcumin at low dose but cautious for chronic and concomitant use of curcumin at a high dose.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.6123