Transmural dispersion of action potential duration and heterogeneous changes in L-type calcium current in rabbit heart three months after myocardial infarction

The transmural dispersion of APD (TD‐APD) and heterogeneous changes in L‐type calcium current (ICa.L) in rabbit hearts were examined 3 months after myocardial infarction. Compared to the control group, APDs of cells from the epimyocyte, midmyocyte, and endomyocyte layers remote from the infarct site...

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Bibliographic Details
Published in:Drug development research 2003-01, Vol.58 (1), p.122-124
Main Authors: Ma, Jie, Li, Yang, Zhang, Cun-Tai, Xiao, Jian-Ming, Lu, Zai-Ying
Format: Article
Language:English
Subjects:
action potential duration
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Heart
L-type calcium current
myocardial infarction
transmural dispersion
Vertebrates: cardiovascular system
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Summary:The transmural dispersion of APD (TD‐APD) and heterogeneous changes in L‐type calcium current (ICa.L) in rabbit hearts were examined 3 months after myocardial infarction. Compared to the control group, APDs of cells from the epimyocyte, midmyocyte, and endomyocyte layers remote from the infarct site were all lengthened: TD‐APD was increased (288.32±19.56 ms vs. 210.32±17.43 ms in the control group; P0.05). Compared to the control group, ICa.L density was decreased in the infarct group, the reduction being most prominent in cells from the endomyocyte layer (from 16.12±1.60 pA·pF‐1 to 8.73±0.06 pA·pF‐1, decreased 45.82%), with reductions in cells from the midmyocyte and epimyocyte layers of 39.72% and 37.01%, respectively. There was no significant difference in ICa.L density between the sham‐operated and control groups (P>0.05). Drug Dev. Res. 58:122–124, 2003. © 2003 Wiley‐Liss, Inc.
ISSN:0272-4391
1098-2299
DOI:10.1002/ddr.10140