Thyroid function and volume in epileptic children using carbamazepine, oxcarbazepine and valproate

Background: The aim of the present study was to investigate the effects of carbamazepine (CBZ), oxcarbazepine (OXC), and valproic acid (VPA) on thyroid function and volume in epileptic children. Methods: Fifty‐three epileptic children (age, 3–17 years) treated with OXC (n = 10), CBZ (n = 12), or VPA...

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Bibliographic Details
Published in:Pediatrics international 2007-12, Vol.49 (6), p.822-826
Main Authors: HIRFANOGLU, TUGBA, SERDAROGLU, AYSE, CAMURDAN, ORHUN, CANSU, ALI, BIDECI, AYSUN, CINAZ, PEYAMI, GUCUYENER, KIVILCIM
Format: Article
Language:English
Subjects:
Adolescent
anti-epileptic drugs
Anticonvulsants - pharmacology
Anticonvulsants - therapeutic use
Carbamazepine - analogs & derivatives
Carbamazepine - pharmacology
Carbamazepine - therapeutic use
Child
Child, Preschool
children
epilepsy
Epilepsy - drug therapy
Epilepsy - physiopathology
Female
Humans
Hypothyroidism - chemically induced
Hypothyroidism - diagnosis
Male
Organ Size - drug effects
thyroid function
Thyroid Function Tests
Thyroid Gland - anatomy & histology
Thyroid Gland - drug effects
Thyroid Gland - physiology
thyroid volume
Thyrotropin - blood
Valproic Acid - pharmacology
Valproic Acid - therapeutic use
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Summary:Background: The aim of the present study was to investigate the effects of carbamazepine (CBZ), oxcarbazepine (OXC), and valproic acid (VPA) on thyroid function and volume in epileptic children. Methods: Fifty‐three epileptic children (age, 3–17 years) treated with OXC (n = 10), CBZ (n = 12), or VPA (n = 31) at least for 1 year were evaluated in terms of thyroid hormones, thyroid‐stimulating hormone (TSH) levels, response to thyrotropin‐releasing hormone (TRH) stimulation test, and thyroid volumes. Results: The patients in the OXC and CBZ groups had similar total thyroxin (TT4) and free T4 (fT4) median levels that were significantly lower than those of the VPA group (P  0.05). Conclusions: Thyroid function should be evaluated periodically in children using CBZ, OXC or VPA. The children taking VPA seems to be at greater risk compared to children onr CBZ or OXC therapy. Except for the basal TSH values in the VPA group, the parameters predictive for the subclinical hypothyroid status remain to be evaluated in further studies.
ISSN:1328-8067
1442-200X
DOI:10.1111/j.1442-200X.2007.02456.x