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Thyroid function and volume in epileptic children using carbamazepine, oxcarbazepine and valproate
Background: The aim of the present study was to investigate the effects of carbamazepine (CBZ), oxcarbazepine (OXC), and valproic acid (VPA) on thyroid function and volume in epileptic children. Methods: Fifty‐three epileptic children (age, 3–17 years) treated with OXC (n = 10), CBZ (n = 12), or VPA...
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| Published in: | Pediatrics international 2007-12, Vol.49 (6), p.822-826 |
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| container_title | Pediatrics international |
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| creator | HIRFANOGLU, TUGBA SERDAROGLU, AYSE CAMURDAN, ORHUN CANSU, ALI BIDECI, AYSUN CINAZ, PEYAMI GUCUYENER, KIVILCIM |
| description | Background: The aim of the present study was to investigate the effects of carbamazepine (CBZ), oxcarbazepine (OXC), and valproic acid (VPA) on thyroid function and volume in epileptic children.
Methods: Fifty‐three epileptic children (age, 3–17 years) treated with OXC (n = 10), CBZ (n = 12), or VPA (n = 31) at least for 1 year were evaluated in terms of thyroid hormones, thyroid‐stimulating hormone (TSH) levels, response to thyrotropin‐releasing hormone (TRH) stimulation test, and thyroid volumes.
Results: The patients in the OXC and CBZ groups had similar total thyroxin (TT4) and free T4 (fT4) median levels that were significantly lower than those of the VPA group (P 0.05).
Conclusions: Thyroid function should be evaluated periodically in children using CBZ, OXC or VPA. The children taking VPA seems to be at greater risk compared to children onr CBZ or OXC therapy. Except for the basal TSH values in the VPA group, the parameters predictive for the subclinical hypothyroid status remain to be evaluated in further studies. |
| doi_str_mv | 10.1111/j.1442-200X.2007.02456.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_20464324</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20464324</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5156-53d7755e1ecbf0f4cbdde0d441e3801072f809090479e51654c521071e4cd5ba3</originalsourceid><addsrcrecordid>eNqNkE1v1DAQhi1ERUvhL1Q-cSKp7dix98AB9WMpqgpCZenNcuwJ9ZKPrZ3ALr8ep1m1V2xpPJ553xnpQQhTktN0Ttc55ZxljJC7PAWZE8ZFmW9foKOnxsuUF0xlipTyEL2OcU0IUVLxV-iQKsIFk4sjVN3e70LvHa7Hzg6-77DpHP7dN2ML2HcYNr6BzeAttve-cQE6PEbf_cTWhMq05m8SdPAe99vHwvydZ5hmE3ozwBt0UJsmwtv9e4y-X17cnn3Krr8sr84-XmdWUFFmonBSCgEUbFWTmtvKOSCOcwqFIpRIViuySJfLBQhaCm4FS2UK3DpRmeIYvZvnprUPI8RBtz5aaBrTQT9GzQgvecF4EqpZaEMfY4Bab4JvTdhpSvTEV6_1hFFPGKcg9SNfvU3Wk_2OsWrBPRv3QJPgwyz4k7jt_nuw_npxPmXJn81-HwfYPvlN-KVLWUihf9ws9eqbWq4-3xR6VfwDSNmZ3g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20464324</pqid></control><display><type>article</type><title>Thyroid function and volume in epileptic children using carbamazepine, oxcarbazepine and valproate</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>HIRFANOGLU, TUGBA ; SERDAROGLU, AYSE ; CAMURDAN, ORHUN ; CANSU, ALI ; BIDECI, AYSUN ; CINAZ, PEYAMI ; GUCUYENER, KIVILCIM</creator><creatorcontrib>HIRFANOGLU, TUGBA ; SERDAROGLU, AYSE ; CAMURDAN, ORHUN ; CANSU, ALI ; BIDECI, AYSUN ; CINAZ, PEYAMI ; GUCUYENER, KIVILCIM</creatorcontrib><description>Background: The aim of the present study was to investigate the effects of carbamazepine (CBZ), oxcarbazepine (OXC), and valproic acid (VPA) on thyroid function and volume in epileptic children.
Methods: Fifty‐three epileptic children (age, 3–17 years) treated with OXC (n = 10), CBZ (n = 12), or VPA (n = 31) at least for 1 year were evaluated in terms of thyroid hormones, thyroid‐stimulating hormone (TSH) levels, response to thyrotropin‐releasing hormone (TRH) stimulation test, and thyroid volumes.
Results: The patients in the OXC and CBZ groups had similar total thyroxin (TT4) and free T4 (fT4) median levels that were significantly lower than those of the VPA group (P < 0.016). Total tri‐iodothyrosin median levels were lower in the CBZ group compared to the VPA group (P < 0.016). Basal TSH levels and thyroid volumes were similar in all groups (P > 0.016). One child from the OXC group (10%), one from the CBZ group (%8.3), and six from the VPA group (19.3%) had hypothyroidic status according to the TRH stimulation test. No statistically significant correlations were found between thyroid gland volume and thyroid function variables and between anti‐epileptic drug receiving time and thyroid function or thyroid volume, respectively, in any of the groups (P > 0.05).
Conclusions: Thyroid function should be evaluated periodically in children using CBZ, OXC or VPA. The children taking VPA seems to be at greater risk compared to children onr CBZ or OXC therapy. Except for the basal TSH values in the VPA group, the parameters predictive for the subclinical hypothyroid status remain to be evaluated in further studies.</description><identifier>ISSN: 1328-8067</identifier><identifier>EISSN: 1442-200X</identifier><identifier>DOI: 10.1111/j.1442-200X.2007.02456.x</identifier><identifier>PMID: 18045279</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Adolescent ; anti-epileptic drugs ; Anticonvulsants - pharmacology ; Anticonvulsants - therapeutic use ; Carbamazepine - analogs & derivatives ; Carbamazepine - pharmacology ; Carbamazepine - therapeutic use ; Child ; Child, Preschool ; children ; epilepsy ; Epilepsy - drug therapy ; Epilepsy - physiopathology ; Female ; Humans ; Hypothyroidism - chemically induced ; Hypothyroidism - diagnosis ; Male ; Organ Size - drug effects ; thyroid function ; Thyroid Function Tests ; Thyroid Gland - anatomy & histology ; Thyroid Gland - drug effects ; Thyroid Gland - physiology ; thyroid volume ; Thyrotropin - blood ; Valproic Acid - pharmacology ; Valproic Acid - therapeutic use</subject><ispartof>Pediatrics international, 2007-12, Vol.49 (6), p.822-826</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5156-53d7755e1ecbf0f4cbdde0d441e3801072f809090479e51654c521071e4cd5ba3</citedby><cites>FETCH-LOGICAL-c5156-53d7755e1ecbf0f4cbdde0d441e3801072f809090479e51654c521071e4cd5ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18045279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HIRFANOGLU, TUGBA</creatorcontrib><creatorcontrib>SERDAROGLU, AYSE</creatorcontrib><creatorcontrib>CAMURDAN, ORHUN</creatorcontrib><creatorcontrib>CANSU, ALI</creatorcontrib><creatorcontrib>BIDECI, AYSUN</creatorcontrib><creatorcontrib>CINAZ, PEYAMI</creatorcontrib><creatorcontrib>GUCUYENER, KIVILCIM</creatorcontrib><title>Thyroid function and volume in epileptic children using carbamazepine, oxcarbazepine and valproate</title><title>Pediatrics international</title><addtitle>Pediatr Int</addtitle><description>Background: The aim of the present study was to investigate the effects of carbamazepine (CBZ), oxcarbazepine (OXC), and valproic acid (VPA) on thyroid function and volume in epileptic children.
Methods: Fifty‐three epileptic children (age, 3–17 years) treated with OXC (n = 10), CBZ (n = 12), or VPA (n = 31) at least for 1 year were evaluated in terms of thyroid hormones, thyroid‐stimulating hormone (TSH) levels, response to thyrotropin‐releasing hormone (TRH) stimulation test, and thyroid volumes.
Results: The patients in the OXC and CBZ groups had similar total thyroxin (TT4) and free T4 (fT4) median levels that were significantly lower than those of the VPA group (P < 0.016). Total tri‐iodothyrosin median levels were lower in the CBZ group compared to the VPA group (P < 0.016). Basal TSH levels and thyroid volumes were similar in all groups (P > 0.016). One child from the OXC group (10%), one from the CBZ group (%8.3), and six from the VPA group (19.3%) had hypothyroidic status according to the TRH stimulation test. No statistically significant correlations were found between thyroid gland volume and thyroid function variables and between anti‐epileptic drug receiving time and thyroid function or thyroid volume, respectively, in any of the groups (P > 0.05).
Conclusions: Thyroid function should be evaluated periodically in children using CBZ, OXC or VPA. The children taking VPA seems to be at greater risk compared to children onr CBZ or OXC therapy. Except for the basal TSH values in the VPA group, the parameters predictive for the subclinical hypothyroid status remain to be evaluated in further studies.</description><subject>Adolescent</subject><subject>anti-epileptic drugs</subject><subject>Anticonvulsants - pharmacology</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Carbamazepine - analogs & derivatives</subject><subject>Carbamazepine - pharmacology</subject><subject>Carbamazepine - therapeutic use</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>children</subject><subject>epilepsy</subject><subject>Epilepsy - drug therapy</subject><subject>Epilepsy - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypothyroidism - chemically induced</subject><subject>Hypothyroidism - diagnosis</subject><subject>Male</subject><subject>Organ Size - drug effects</subject><subject>thyroid function</subject><subject>Thyroid Function Tests</subject><subject>Thyroid Gland - anatomy & histology</subject><subject>Thyroid Gland - drug effects</subject><subject>Thyroid Gland - physiology</subject><subject>thyroid volume</subject><subject>Thyrotropin - blood</subject><subject>Valproic Acid - pharmacology</subject><subject>Valproic Acid - therapeutic use</subject><issn>1328-8067</issn><issn>1442-200X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqNkE1v1DAQhi1ERUvhL1Q-cSKp7dix98AB9WMpqgpCZenNcuwJ9ZKPrZ3ALr8ep1m1V2xpPJ553xnpQQhTktN0Ttc55ZxljJC7PAWZE8ZFmW9foKOnxsuUF0xlipTyEL2OcU0IUVLxV-iQKsIFk4sjVN3e70LvHa7Hzg6-77DpHP7dN2ML2HcYNr6BzeAttve-cQE6PEbf_cTWhMq05m8SdPAe99vHwvydZ5hmE3ozwBt0UJsmwtv9e4y-X17cnn3Krr8sr84-XmdWUFFmonBSCgEUbFWTmtvKOSCOcwqFIpRIViuySJfLBQhaCm4FS2UK3DpRmeIYvZvnprUPI8RBtz5aaBrTQT9GzQgvecF4EqpZaEMfY4Bab4JvTdhpSvTEV6_1hFFPGKcg9SNfvU3Wk_2OsWrBPRv3QJPgwyz4k7jt_nuw_npxPmXJn81-HwfYPvlN-KVLWUihf9ws9eqbWq4-3xR6VfwDSNmZ3g</recordid><startdate>200712</startdate><enddate>200712</enddate><creator>HIRFANOGLU, TUGBA</creator><creator>SERDAROGLU, AYSE</creator><creator>CAMURDAN, ORHUN</creator><creator>CANSU, ALI</creator><creator>BIDECI, AYSUN</creator><creator>CINAZ, PEYAMI</creator><creator>GUCUYENER, KIVILCIM</creator><general>Blackwell Publishing Asia</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>200712</creationdate><title>Thyroid function and volume in epileptic children using carbamazepine, oxcarbazepine and valproate</title><author>HIRFANOGLU, TUGBA ; SERDAROGLU, AYSE ; CAMURDAN, ORHUN ; CANSU, ALI ; BIDECI, AYSUN ; CINAZ, PEYAMI ; GUCUYENER, KIVILCIM</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5156-53d7755e1ecbf0f4cbdde0d441e3801072f809090479e51654c521071e4cd5ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>anti-epileptic drugs</topic><topic>Anticonvulsants - pharmacology</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Carbamazepine - analogs & derivatives</topic><topic>Carbamazepine - pharmacology</topic><topic>Carbamazepine - therapeutic use</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>children</topic><topic>epilepsy</topic><topic>Epilepsy - drug therapy</topic><topic>Epilepsy - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypothyroidism - chemically induced</topic><topic>Hypothyroidism - diagnosis</topic><topic>Male</topic><topic>Organ Size - drug effects</topic><topic>thyroid function</topic><topic>Thyroid Function Tests</topic><topic>Thyroid Gland - anatomy & histology</topic><topic>Thyroid Gland - drug effects</topic><topic>Thyroid Gland - physiology</topic><topic>thyroid volume</topic><topic>Thyrotropin - blood</topic><topic>Valproic Acid - pharmacology</topic><topic>Valproic Acid - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HIRFANOGLU, TUGBA</creatorcontrib><creatorcontrib>SERDAROGLU, AYSE</creatorcontrib><creatorcontrib>CAMURDAN, ORHUN</creatorcontrib><creatorcontrib>CANSU, ALI</creatorcontrib><creatorcontrib>BIDECI, AYSUN</creatorcontrib><creatorcontrib>CINAZ, PEYAMI</creatorcontrib><creatorcontrib>GUCUYENER, KIVILCIM</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Pediatrics international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HIRFANOGLU, TUGBA</au><au>SERDAROGLU, AYSE</au><au>CAMURDAN, ORHUN</au><au>CANSU, ALI</au><au>BIDECI, AYSUN</au><au>CINAZ, PEYAMI</au><au>GUCUYENER, KIVILCIM</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thyroid function and volume in epileptic children using carbamazepine, oxcarbazepine and valproate</atitle><jtitle>Pediatrics international</jtitle><addtitle>Pediatr Int</addtitle><date>2007-12</date><risdate>2007</risdate><volume>49</volume><issue>6</issue><spage>822</spage><epage>826</epage><pages>822-826</pages><issn>1328-8067</issn><eissn>1442-200X</eissn><abstract>Background: The aim of the present study was to investigate the effects of carbamazepine (CBZ), oxcarbazepine (OXC), and valproic acid (VPA) on thyroid function and volume in epileptic children.
Methods: Fifty‐three epileptic children (age, 3–17 years) treated with OXC (n = 10), CBZ (n = 12), or VPA (n = 31) at least for 1 year were evaluated in terms of thyroid hormones, thyroid‐stimulating hormone (TSH) levels, response to thyrotropin‐releasing hormone (TRH) stimulation test, and thyroid volumes.
Results: The patients in the OXC and CBZ groups had similar total thyroxin (TT4) and free T4 (fT4) median levels that were significantly lower than those of the VPA group (P < 0.016). Total tri‐iodothyrosin median levels were lower in the CBZ group compared to the VPA group (P < 0.016). Basal TSH levels and thyroid volumes were similar in all groups (P > 0.016). One child from the OXC group (10%), one from the CBZ group (%8.3), and six from the VPA group (19.3%) had hypothyroidic status according to the TRH stimulation test. No statistically significant correlations were found between thyroid gland volume and thyroid function variables and between anti‐epileptic drug receiving time and thyroid function or thyroid volume, respectively, in any of the groups (P > 0.05).
Conclusions: Thyroid function should be evaluated periodically in children using CBZ, OXC or VPA. The children taking VPA seems to be at greater risk compared to children onr CBZ or OXC therapy. Except for the basal TSH values in the VPA group, the parameters predictive for the subclinical hypothyroid status remain to be evaluated in further studies.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>18045279</pmid><doi>10.1111/j.1442-200X.2007.02456.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent anti-epileptic drugs Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Carbamazepine - analogs & derivatives Carbamazepine - pharmacology Carbamazepine - therapeutic use Child Child, Preschool children epilepsy Epilepsy - drug therapy Epilepsy - physiopathology Female Humans Hypothyroidism - chemically induced Hypothyroidism - diagnosis Male Organ Size - drug effects thyroid function Thyroid Function Tests Thyroid Gland - anatomy & histology Thyroid Gland - drug effects Thyroid Gland - physiology thyroid volume Thyrotropin - blood Valproic Acid - pharmacology Valproic Acid - therapeutic use |
| title | Thyroid function and volume in epileptic children using carbamazepine, oxcarbazepine and valproate |
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