Compatibility effects of herb pair Phellodendri chinensis cortex and Anemarrhenae rhizoma on benign prostatic hyperplasia using targeted metabolomics

Phellodendri chinensis cortex (P. C. cortex) and Anemarrhenae rhizoma (A. rhizoma) herb pair is a core component of traditional Chinese medicines used to treat inflammation and benign prostatic hyperplasia (BPH). The present study was designed to profile the arachidonic acid (AA) metabolomic charact...

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Bibliographic Details
Published in:Biomedical chromatography 2018-10, Vol.32 (10), p.e4296-n/a
Main Authors: Zhao, Xiaoning, Li, Yiran, Huai, Jiaxin, Cheng, Congcong, Zhang, Teng, Xie, Linlin, Wang, Siqi, Zhang, Meng, Dai, Ronghua
Format: Article
Language:English
Subjects:
Anemarrhenae rhizoma
arachidonic acid
benign prostatic hyperplasia
metabolomics
Phellodendri chinensis cortex
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Summary:Phellodendri chinensis cortex (P. C. cortex) and Anemarrhenae rhizoma (A. rhizoma) herb pair is a core component of traditional Chinese medicines used to treat inflammation and benign prostatic hyperplasia (BPH). The present study was designed to profile the arachidonic acid (AA) metabolomic characteristics in rat plasma and prostate after being treated with P. C. cortex and A. rhizoma as well as their combination. Plasma and prostate samples from sham group, BPH model group, herb pair group and two single herb groups were collected on days 7, 14, 21 and 28. Then, a systemic metabolomic analysis based on UFLC‐MS/MS was employed to quantify AA and its cyclooxygenase and lipoxygenase pathway metabolites (15‐HETE, 12‐HETE, 5‐HETE, AA, PGI2, PGF2α, 8‐HETE, PGD2, PGE2 and LTB4). The results demonstrated that BPH led a significant increase of 10 biomarkers in plasma and tissue (p 
ISSN:0269-3879
1099-0801
DOI:10.1002/bmc.4296