Rome IV Diagnostic Questionnaire Complements Patient Assessment of Gastrointestinal Symptoms for Patients with Gastroparesis Symptoms

• Published in: Digestive diseases and sciences 2018-09, Vol.63 (9), p.2231-2243
• Main Authors: Jehangir, Asad, Parkman, Henry P.
• Format: Article
• Language: English
• Subjects: Analysis; Biochemistry; Care and treatment; Diagnosis; Gastroenterology; Gastroesophageal reflux; Gastrointestinal diseases; Hepatology; Medical diagnosis; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Nausea; Oncology; Original Article; Pain; Patient assessment; Questionnaires; Surveys; Transplant Surgery; Vomiting
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1007/s10620-018-5125-1

Background Patient assessment of upper gastrointestinal symptoms (PAGI-SYM) questionnaire assesses severity of gastrointestinal symptoms in gastroparesis (Gp), dyspepsia, and gastroesophageal reflux disease. Rome IV Diagnostic Questionnaire (R4DQ), used to diagnose various functional gastrointestinal disorders, may also help to better understand symptoms of Gp. Aim To assess patients with Gp comparing PAGI-SYM to R4DQ. Methods Patients with symptoms of Gp referred to our center from May 2016 to January 2018 filled out PAGI-SYM and R4DQ. Results Out of 357 patients, 225 had delayed gastric emptying including 121 with idiopathic gastroparesis (IGp), 60 with diabetic gastroparesis (DGp), 25 with atypical Gp, and 19 with postsurgical gastroparesis (PSGp). Using PAGI-SYM, DGp had more severe retching and vomiting compared to IGp. PSGp had more severe upper abdominal pain compared to IGp. Using R4DQ, the average number of Rome IV diagnoses that Gp patients met criteria was 2.1 ± 0.1. Most Gp patients had functional dyspepsia ( n  = 197, 90.8%) and chronic nausea and vomiting syndrome (CNVS) ( n  = 181, 83.4%). Postprandial distress syndrome (PDS) was present in 189 patients (88.3%), and epigastric pain syndrome in 126 patients (59.8%). The combination of PDS and CNVS was seen in 76.5% of Gp patients. Conclusions In this study, Gp patients were characterized using the PAGI-SYM and R4DQ. DGp had more severe retching and vomiting, while PSGp had more severe upper abdominal pain. PDS and CNVS were the most prevalent Rome IV diagnoses. The combination of PDS and CNVS was typically seen in patients with Gp. R4DQ can be helpful to characterize Gp patients.