The Effect of IL-13R·2 on IL-13 Transgene-Induced Experimental Eosinophilic Esophagitis

Notably, IL-13Ra2 deletion was associated with significant esophageal eosinophilia (15.4% increase from double transgenic mice, P=0.4), epithelial thickening (28.8% increase, P=0.03), BrdU incorporation (194% increase, P=0.003), collagen deposition (61% increase, P=0.04) and esophageal circumference...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2009-03, Vol.123 (3), p.725-725
Main Authors: Zuo, L, Mingler, M, Cole, E, Blanchard, C, Finkelman, F.D, Fulkerson, P.C, Rothenberg, M.E
Format: Article
Language:English
Subjects:
Allergy and Immunology
Rodents
Transgenic animals
Online Access:Get full text
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Summary:Notably, IL-13Ra2 deletion was associated with significant esophageal eosinophilia (15.4% increase from double transgenic mice, P=0.4), epithelial thickening (28.8% increase, P=0.03), BrdU incorporation (194% increase, P=0.003), collagen deposition (61% increase, P=0.04) and esophageal circumference (27% increase, P=0.046).
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2009.01.009