Development Of An In Vivo Model For Non Allergic Rhinitis Using MRI To Quantify The Nasal Parasympathetic Reflex Response Following Capsaicin, Hypertonic Saline and Cold Dry Air Challenges

To develop a strategy to study this disease, a preclinical guinea pig model of NAR was developed where neuronal stimulants such as capsaicin, hypertonic saline (HTS) and cold dry air (CDA) were unilaterally delivered intranasally.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2009-03, Vol.123 (3), p.727-728
Main Authors: Changani, K, Campbell, S.P, Hotee, S, Pindoria, K, Buxton, N.A, Busza, A.L, Denyer, J.C
Format: Article
Language:English
Subjects:
Allergies
Allergy and Immunology
Nose
Online Access:Get full text
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Description
Summary:To develop a strategy to study this disease, a preclinical guinea pig model of NAR was developed where neuronal stimulants such as capsaicin, hypertonic saline (HTS) and cold dry air (CDA) were unilaterally delivered intranasally.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2009.01.021