Natural Anti-Amyloid-beta Antibodies in Intravenous Immunoglobulin (IVIG) Preparation Attenuate Amyloid beta-Induced Neurotoxicity in vitro

Preincubation of Aß42 with monoclonal anti-Aß42 antibodies decreased the Aß42 induced cytotoxicity in PC-12 cells. 6E10, a monoclonal antibody that shows therapeutic effects in murine models of AD, was most effective.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2009-03, Vol.123 (3), p.726-726
Main Authors: Hermann, C, Schwarz, H.P, Ehrlich, H, Reipert, B.M, Olas, K
Format: Article
Language:English
Subjects:
Allergy and Immunology
Cytotoxicity
Medical research
Neurotoxicity
Online Access:Get full text
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Description
Summary:Preincubation of Aß42 with monoclonal anti-Aß42 antibodies decreased the Aß42 induced cytotoxicity in PC-12 cells. 6E10, a monoclonal antibody that shows therapeutic effects in murine models of AD, was most effective.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2009.01.013