Lanthanum deposition corresponds to white lesions in the stomach

Although lanthanum deposition in the stomach has been most frequently reported to occur as white lesions, no study has investigated whether the white lesions observed during esophagogastroduodenoscopy are truly lanthanum-related. Here, we retrospectively investigated the amount of lanthanum in endos...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2018-07, Vol.214 (7), p.934-939
Main Authors: Iwamuro, Masaya, Urata, Haruo, Tanaka, Takehiro, Kawano, Seiji, Kawahara, Yoshiro, Kimoto, Katsuhiko, Okada, Hiroyuki
Format: Article
Language:English
Subjects:
Esophagogastroduodenoscopy
Hyperphosphatemia
Lanthanum carbonate
Scanning electron microscopy analysis
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Summary:Although lanthanum deposition in the stomach has been most frequently reported to occur as white lesions, no study has investigated whether the white lesions observed during esophagogastroduodenoscopy are truly lanthanum-related. Here, we retrospectively investigated the amount of lanthanum in endoscopic biopsy specimens. We reviewed four patients showing gastric white spots or annular whitish mucosa in the gastric white lesions (Bw) and peripheral mucosa where the white substance was not endoscopically observed (Bp) during biopsy. We also reviewed three patients with diffuse whitish mucosa and three patients with no whitish lesions. We performed scanning electron microscopy and energy dispersive X-ray spectrometry to quantify the lanthanum elements (wt%) in the biopsy specimens. The amount of lanthanum in the Bw ranged from 0.15–0.31 wt%, whereas that of Bp was 0.00–0.13 wt%. The difference was statistically significant (P 
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2018.05.024