Cytotoxicity of cycloartane triterpenoids from aerial part of Cimicifuga foetida

Our previous study had demonstrated cytotoxicity of EtOAc fraction from aerial part of Cimicifuga foetida on various cancer cell lines. In the present study, we investigated the cytotoxicity of five cycloartane triterpenoids isolated from the EtOAc fraction. Compounds ( 1,2,3) showed moderate cytoto...

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Bibliographic Details
Published in:Fitoterapia 2006, Vol.77 (1), p.39-42
Main Authors: Tian, Ze, Pan, Rui Le, Si, JianYong, Xiao, Pei Gen
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Line
Cimicifuga
Cimicifuga - chemistry
Cycloartanes
Cytotoxicity
General pharmacology
Glycosides
Hepatocytes - drug effects
Lanosterol - analogs & derivatives
Medical sciences
Mice
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Components, Aerial - chemistry
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - toxicity
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - toxicity
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Summary:Our previous study had demonstrated cytotoxicity of EtOAc fraction from aerial part of Cimicifuga foetida on various cancer cell lines. In the present study, we investigated the cytotoxicity of five cycloartane triterpenoids isolated from the EtOAc fraction. Compounds ( 1,2,3) showed moderate cytotoxic activity on R-HepG2 cells and drug resistant sub line R-HepG2 but exhibited less toxicity against primary cultured normal mouse hepatocytes. Compounds ( 4) and ( 5) were inactive on all tested cell lines.
ISSN:0367-326X
DOI:10.1016/j.fitote.2005.08.001