Identification of cytotoxic constituent of Indonesian sponge Kaliapsis sp. (Bowerbank)

Identification of cytotoxic constituent of Indonesian sponge Kaliapsis sp. has been conducted. The structure identification was judged based on the spectroscopic data, namely, ultraviolet, MS, one and two-dimensional 1H-NMR and 13C-NMR methods. The cytotoxic constituent was identified as 1-(tetrahyd...

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Bibliographic Details
Published in:Pakistan journal of biological sciences 2008-11, Vol.11 (22), p.2560-2566
Main Authors: Setyowati, E P, Jenie, U A, Sudarsono, Kardono, L B S, Rahmat, R
Format: Article
Language:English
Subjects:
Animals
Biological Products - chemistry
Biological Products - isolation & purification
Biological Products - pharmacology
Cell Line, Tumor
Cell Proliferation - drug effects
Cytotoxins - chemistry
Cytotoxins - isolation & purification
Cytotoxins - pharmacology
Furans - chemistry
Furans - isolation & purification
Furans - pharmacology
HeLa Cells
Humans
Indonesia
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Structure
Porifera
Porifera - chemistry
Pyrimidines - chemistry
Pyrimidines - isolation & purification
Pyrimidines - pharmacology
Solubility
Spectrophotometry, Infrared
Thymine - analogs & derivatives
Thymine - chemistry
Thymine - isolation & purification
Thymine - pharmacology
Transition Temperature
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Summary:Identification of cytotoxic constituent of Indonesian sponge Kaliapsis sp. has been conducted. The structure identification was judged based on the spectroscopic data, namely, ultraviolet, MS, one and two-dimensional 1H-NMR and 13C-NMR methods. The cytotoxic constituent was identified as 1-(tetrahydro-4-hydroxy-5-(hydroxymethyl)furan-2-yl)-5-methyl pyrimidine-2,4(1H,3H)-dione. This constituent hasn't been isolated from sponges as natural product.
ISSN:1028-8880
DOI:10.3923/pjbs.2008.2560.2566