A journey from neocortex to hippocampus

In the mid-1960s, it was generally agreed that the engram, the neural trace of previously experienced events, must be encoded by Hebb-like neurons in which synaptic efficacy could be modified by activity. Here, I describe my attempts as a PhD student at McGill University, Montreal, to find rules gov...

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Bibliographic Details
Published in:Philosophical transactions of the Royal Society of London. Series B. Biological sciences 2003-04, Vol.358 (1432), p.621-623
Main Author: Bliss, T. V. P.
Format: Article
Language:English
Subjects:
Animals
Canada
Cell physiology
Electrodes
Hebb
Hippocampus
Hippocampus - physiology
History
History, 20th Century
Learning
Long term potentiation
Long-Term Potentiation - physiology
Medical research
Memory
Memory - physiology
Neocortex
Neocortex - physiology
Neocortex To Hippocampus
Neuronal Plasticity - physiology
Neurons
Neurophysiology
Neurophysiology - history
Synapses
Synaptic Plasticity
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Summary:In the mid-1960s, it was generally agreed that the engram, the neural trace of previously experienced events, must be encoded by Hebb-like neurons in which synaptic efficacy could be modified by activity. Here, I describe my attempts as a PhD student at McGill University, Montreal, to find rules governing cortical plasticity in the neocortex, and having failed, why the hippocampus seemed to offer a far better prospect.
ISSN:0962-8436
1471-2970
DOI:10.1098/rstb.2002.1227