Self-injury behaviour induced by intraplantar carrageenan infiltration: a model of tonic nociception

The research of chronic nociception using whole animals is an approach plagued with methodological drawbacks within the ethical realm, as well as difficulties in the analysis and interpretation of time dependent results. On this work, we propose an experimental model that displays tonic nociception...

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Bibliographic Details
Published in:Brain research. Brain research protocols 2004-04, Vol.13 (1), p.37-44
Main Authors: López-Avila, Alberto, Rodrı&#x0301, guez-Manzo, Gabriela, Coffeen, Ulises, del Ángel, Rosendo, Pellicer, Francisco
Format: Article
Language:English
Subjects:
Animal model
Animals
Body Weight - drug effects
Body Weight - physiology
Carrageenan - adverse effects
Chronic Disease
Chronic nociception
Disease Models, Animal
Foot - innervation
Foot - physiopathology
Inflammation
Inflammation - chemically induced
Inflammation - pathology
Inflammation - physiopathology
Inflammation Mediators - adverse effects
Male
Nociceptors - drug effects
Nociceptors - physiology
Pain
Pain - chemically induced
Pain - physiopathology
Pain Measurement - ethics
Pain Measurement - methods
Rat
Rats
Rats, Wistar
Reproducibility of Results
Self-Injurious Behavior - chemically induced
Self-Injurious Behavior - physiopathology
Self-injury behaviour
Sexual Behavior, Animal - drug effects
Sexual Behavior, Animal - physiology
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Summary:The research of chronic nociception using whole animals is an approach plagued with methodological drawbacks within the ethical realm, as well as difficulties in the analysis and interpretation of time dependent results. On this work, we propose an experimental model that displays tonic nociception measured as a quantifiable self-injury behaviour (SIB) produced by the inflammation of soft tissue located in the paw of the rat elicited by carrageenan 1% (CAR) infiltration. We established five categories or levels for the analysis of the self-injury behaviour reflecting the intensity of rat nociception triggered by CAR infiltration. In addition, we determine that this model does not induce inescapable pain by noticing no significant differences when measuring weight gain and sexual behaviour. We propose this nociception model as physiologically and ethically appropriate for the study of long-lasting nociception.
ISSN:1385-299X
DOI:10.1016/j.brainresprot.2004.01.001