Safety evaluation of the aqueous extract of Leonotis leonurus shoots in rats

The aqueous extract from Leonotis leonurus (L) R.Br. (Lamiaceae) shoots was evaluated in female rats for its acute, sub acute, and chronic toxicity together with hematological, biochemical, and histopathological changes. In the acute toxicity test, the extract caused death in animals receiving 3200 ...

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Bibliographic Details
Published in:Human & experimental toxicology 2008-11, Vol.27 (11), p.837-843
Main Authors: Maphosa, V, Masika, PJ, Adedapo, AA
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal - drug effects
Biological and medical sciences
Blood Cell Count
Blood Chemical Analysis
Body Weight - drug effects
Female
General pharmacology
Herbal medicine
Lamiaceae
Lamiaceae - toxicity
Leonotis leonurus
Medical sciences
Nigeria
Organ Size - drug effects
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - toxicity
Plant Poisoning - pathology
Plant poisons toxicology
Plant Shoots - chemistry
Rats
Rats, Wistar
Rodents
Toxicity
Toxicology
Water-Electrolyte Balance - drug effects
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Summary:The aqueous extract from Leonotis leonurus (L) R.Br. (Lamiaceae) shoots was evaluated in female rats for its acute, sub acute, and chronic toxicity together with hematological, biochemical, and histopathological changes. In the acute toxicity test, the extract caused death in animals receiving 3200 mg/kg dose. The extract also caused significant (P 
ISSN:0960-3271
1477-0903
DOI:10.1177/0960327108099533