One bis-indole alkaloid-voacamine from Voacanga africana Stapf: biological activity evaluation of PTP1B in vitro utilizing enzymology method based on SPRi expriment

One known bis-indole alkaloid-voacamine was isolated from Voacanga africana Stapf and Surface Plasmon Resonance imaging (SPRi) exprement showed that this alkaloid could be combine with Protein Tyrosine Phosphatase1B (PTP1B). Then the PTP1B activity inhibition experiment display that the compound sho...

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Bibliographic Details
Published in:Natural product research 2019-12, Vol.33 (23), p.3459-3463
Main Authors: Wang, Yan-Qiu, Li, Hong-Xiang, Liu, Xiao-Chun, Zhao, Jin-Shuang, Liu, Rong-Qiang, Huai, Wen-ying, Ding, Wei-Jun, Zhang, Tian-E, Deng, Yun
Format: Article
Language:English
Subjects:
Alkaloids - isolation & purification
Alkaloids - pharmacology
Biological activity
Bis-indole alkaloids
Enzymology
Humans
Ibogaine - analogs & derivatives
Ibogaine - isolation & purification
In vitro methods and tests
Indoles
Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors
PTP1B
SPRi
Surface plasmon resonance
Surface Plasmon Resonance - methods
Tyrosine
voacamine
Voacanga - chemistry
Voacanga africana Stapf
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Summary:One known bis-indole alkaloid-voacamine was isolated from Voacanga africana Stapf and Surface Plasmon Resonance imaging (SPRi) exprement showed that this alkaloid could be combine with Protein Tyrosine Phosphatase1B (PTP1B). Then the PTP1B activity inhibition experiment display that the compound showed an outstanding promoting activity to PTP1B.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2018.1480623