An Unexpected FeCl3‑Catalyzed Cascade Reaction of Indoles and o‑Hydroxychalcones for the Assembly of Chromane-Bridged Polycyclic Indoles

An unexpected FeCl3-catalyzed cascade reaction of simple indoles and o-hydroxychalcone was reported, leading to densely functionalized and strained chromane-bridged polycyclic indoles in moderate to good yields. This reaction not only establishes a new transformation of indoles and o-hydroxychalcone...

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Bibliographic Details
Published in:Organic letters 2018-06, Vol.20 (12), p.3451-3454
Main Authors: Wang, Wenbo, Bai, Xuguan, Jin, Shaojing, Guo, Jiaomei, Zhao, Yang, Miao, Hongjie, Zhu, Yanshuo, Wang, Qilin, Bu, Zhanwei
Format: Article
Language:English
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Summary:An unexpected FeCl3-catalyzed cascade reaction of simple indoles and o-hydroxychalcone was reported, leading to densely functionalized and strained chromane-bridged polycyclic indoles in moderate to good yields. This reaction not only establishes a new transformation of indoles and o-hydroxychalcones but also provides an efficient method for the synthesis of structurally complex and congested chromane-bridged polycyclic indoles.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b01107