Intravitreal implantable magnetic micropump for on-demand VEGFR-targeted drug delivery

In this paper, we propose an intravitreal implantable magnetic micropump integrated with micro check valve capable of on-demand vascular endothelial growth factor receptor (VEGFR)-targeted drug delivery for the treatment of age-related macular degeneration, diabetic retinopathy and other eye patholo...

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Bibliographic Details
Published in:Journal of controlled release 2018-08, Vol.283, p.105-112
Main Authors: Wang, Cong, Seo, Seung-Jun, Kim, Jin-Seong, Lee, Se-Hee, Jeon, Jae-Kun, Kim, Jae-Woo, Kim, Ki-Hong, Kim, Jong-Ki, Park, Jungyul
Format: Article
Language:English
Subjects:
Drug delivery
Gold nanoparticle
Magnetic micropump
On-demand
VEGFR
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Summary:In this paper, we propose an intravitreal implantable magnetic micropump integrated with micro check valve capable of on-demand vascular endothelial growth factor receptor (VEGFR)-targeted drug delivery for the treatment of age-related macular degeneration, diabetic retinopathy and other eye pathologies characterized by ocular neoangiogenesis. Precise on-demand drug release is realized by the deflection of the magnetic membrane assembly according to the external magnetic field, and the membrane assembly consists of a thin elastic polydimethylsiloxane (PDMS) membrane and a cylindrical magnetic nanoparticle-PDMS composite block. Additionally, a micro check valve composed of two PDMS layers was integrated into the micropump to realize a diode-like one-directional drug delivery and prevent undesired drug diffusion. For specifically targeting VEGFR and suppression of VEGF-induced proliferation of microvascular endothelial cells, anti-Flt1 gold nanocomplexes are synthesized. In vitro and in vivo experiments and quantitative analysis are carried out in order to verify our proposed concept: precise drug release control according to the external magnetic field, targeting to microvascular endothelial cells, and efficient and on-demand drug delivery from the proposed micropump to the macular area of rabbit's eye. [Display omitted]
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2018.05.030