Sebaceous adenocarcinomas of the major salivary glands: a clinicopathological analysis of 10 cases

Aims Sebaceous carcinomas are uncommon malignant cutaneous tumours originating from the pilosebaceous unit. Although its occurrence is mostly common in peri‐ocular glands, other anatomical regions of the head and neck may be affected, including major and minor salivary glands. Methods and results We...

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Bibliographic Details
Published in:Histopathology 2018-10, Vol.73 (4), p.585-592
Main Authors: Soares, Ciro D, Morais, Thayná M L, Carlos, Roman, Jorge, Jacks, Almeida, Oslei Paes, Carvalho, Maria G F, Altemani, Albina M M
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma, Sebaceous - pathology
adipophilin
Adult
Aged
Aged, 80 and over
Androgen receptors
Biomarkers, Tumor - analysis
Carcinoma
CD34 antigen
Female
Head and neck
Humans
Male
Mandible
Metastases
Metastasis
Middle Aged
MLH1 protein
MSH2 protein
Parotid Neoplasms - pathology
Perforin
Retrospective Studies
Salivary gland
salivary glands
sebaceous adenocarcinoma
Sebaceous Gland Neoplasms - pathology
Submandibular Gland Neoplasms - pathology
Tumors
Vimentin
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Summary:Aims Sebaceous carcinomas are uncommon malignant cutaneous tumours originating from the pilosebaceous unit. Although its occurrence is mostly common in peri‐ocular glands, other anatomical regions of the head and neck may be affected, including major and minor salivary glands. Methods and results We describe a series of sebaceous adenocarcinomas of the parotid and submandibular glands. The mean age was 62.1 (range = 31–90) years. Two patients (20%) presented regional or distant metastasis to mandible and lungs. All cases were positive for cytokeratins (AE1AE3 and CK‐5), epithelial membrane antigen and adipophilin and negative for androgen receptor, Factor XIIIa, S‐100, vimentin and perforin. MLH1 and MSH2 were expressed in the nuclei of most tumour cells, and one case showed loss of MSH2 expression. Proliferative index (assessed by Ki‐67 expression) and microvessel density (CD34‐positive vessels) were higher in metastasis‐associated cases. P63 expression was noted in the periphery of the tumour nests, in the basaloid cells, with a mean of 69.2% nuclear positivity. Conclusions The sebaceous adenocarcinoma of salivary glands is rare and may show an unfavourable outcome; therefore, its correct diagnosis may be challenging. For this reason, immunohistochemical studies, including adipophilin in particular, constitute an important diagnostic tool.
ISSN:0309-0167
1365-2559
DOI:10.1111/his.13664