Bis-reaction-trigger as a strategy to improve the selectivity of fluorescent probes

By the strategy of equipping a fluorophore with two reaction triggers that are tailored to the specific chemistry of peroxynitrite, we have developed a highly selective probe for detecting peroxynitrite in live cells. Sequential response by the two triggers enabled the probe to reveal various degree...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (59), p.8170-8173
Main Authors: Li, Dan, Cheng, Juan, Wang, Cheng-Kun, Ying, Huazhou, Hu, Yongzhou, Han, Feng, Li, Xin
Format: Article
Language:English
Subjects:
Fluorescent indicators
Organic chemistry
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Summary:By the strategy of equipping a fluorophore with two reaction triggers that are tailored to the specific chemistry of peroxynitrite, we have developed a highly selective probe for detecting peroxynitrite in live cells. Sequential response by the two triggers enabled the probe to reveal various degrees of nitrosative stress in live cells via a sensitive emission colour change.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc02830c