High irisin levels in overweight/obese children and its positive correlation with metabolic profile, blood pressure, and endothelial progenitor cells

Irisin is involved in the compensatory mechanisms for metabolic regulation and appears to be associated with glucose homeostasis and lipid profile. However, it's possible implications on obesity-associated cardiometabolic complications have not been completely elucidated. This study aimed to in...

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Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2018-07, Vol.28 (7), p.756-764
Main Authors: De Meneck, F., Victorino de Souza, L., Oliveira, V., do Franco, M.C.
Format: Article
Language:English
Subjects:
Age Factors
Biomarkers - blood
Blood Glucose - metabolism
Blood Pressure
Case-Control Studies
Child
Children
Cross-Sectional Studies
Endothelial progenitor cells
Endothelial Progenitor Cells - pathology
Female
Fibronectins - blood
Humans
Insulin
Insulin - blood
Insulin Resistance
Irisin
Male
Overweight/obesity
Pediatric Obesity - blood
Pediatric Obesity - pathology
Pediatric Obesity - physiopathology
Risk Factors
Up-Regulation
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Summary:Irisin is involved in the compensatory mechanisms for metabolic regulation and appears to be associated with glucose homeostasis and lipid profile. However, it's possible implications on obesity-associated cardiometabolic complications have not been completely elucidated. This study aimed to investigate the association between irisin level and anthropometric data, metabolic parameters, blood pressure, and endothelial progenitor cells (EPCs) level among children with overweight/obesity. This study included 24 children with overweight/obesity (9 girls and 15 boys) and 63 children with normal weight (25 girls and 38 boys). The anthropometric data, blood pressure, blood biochemistry, EPCs and irisin levels were evaluated. Children with overweight/obesity had significantly higher circulating irisin and EPCs levels than those with normal weight (P 
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2018.04.009