To reduce premature drug release while ensuring burst intracellular drug release of solid lipid nanoparticle-based drug delivery system with clathrin modification

Nanoscale drug delivery system (NDDS) with slow premature drug release (PDR) while ensuring burst intracellular drug release (BIDR) is becoming a hot point in NDDS-based nanomedicine. Here we used clathrin to modify a solid lipid nanoparticle (SLN)-based NDDS of salinomycin (SLN-SAL) to prepare NDDS...

Full description

Saved in:
Bibliographic Details
Published in:Nanomedicine 2019-01, Vol.15 (1), p.108-118
Main Authors: Li, Jingcao, Sun, Lan, Liu, Yan, Yao, Hongjuan, Jiang, Shuang, YunzhuPu, Li, Yajuan, Zhang, Yingge
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c356t-cfed7ef09f6ed07e9e3e4e7af8d8b6c7b5cbbe9123cd4ef317e4575565a0486f3
cites cdi_FETCH-LOGICAL-c356t-cfed7ef09f6ed07e9e3e4e7af8d8b6c7b5cbbe9123cd4ef317e4575565a0486f3
container_end_page 118
container_issue 1
container_start_page 108
container_title Nanomedicine
container_volume 15
creator Li, Jingcao
Sun, Lan
Liu, Yan
Yao, Hongjuan
Jiang, Shuang
YunzhuPu
Li, Yajuan
Zhang, Yingge
description Nanoscale drug delivery system (NDDS) with slow premature drug release (PDR) while ensuring burst intracellular drug release (BIDR) is becoming a hot point in NDDS-based nanomedicine. Here we used clathrin to modify a solid lipid nanoparticle (SLN)-based NDDS of salinomycin (SLN-SAL) to prepare NDDS with reduced PDR while ensuring BIDR. Drug-release-kinetic experiments revealed that clathrin modified SLN-SAL (CMSLN-SAL) reduced PDR while ensured BIDR of its prototype NDDS, SLN-SAL. Mechanism experiments revealed that clathrin modification reduced PDR of SLN-SAL through increasing the mechanical strength of SLN-SAL and ensured BIDR of SLN-SAL through lipid membrane fusion after its clathrin shell was de-polymerized by a cytoplasm enzyme, HSC70. In addition, CMSLN-SAL had significantly higher intracellular uptake and stronger inhibitive effects on cancer cells than that of SLN-SAL. These results demonstrated that clathrin modification is an effective way to reduce PDR while ensuring BIDR and increasing the anticancer effects of SLN-based NDDS. The clathrin-shell of clathrin-modified solid lipid nanoparticle-based nanoscale drug delivery system of salinomycin (CMSLN-SAL) works as a cable net to resist internal osmotic pressure to block particle expending and as a cage-like scaffold to resist external pressure exerted by the blood flow at the artery bifurcation and the mouth piece of vascular clefts to block particle deformation, and thereby to reduce the drug loss in transportation, namely, the premature drug release. In tumor cells, the clathrin shell of CMSLN-SAL is depolymerized by HSC70 and the inner SLN-SAL is freed in cytosol to ensure the intracellular burst drug release. [Display omitted]
doi_str_mv 10.1016/j.nano.2018.05.014
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2049563374</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1549963418301060</els_id><sourcerecordid>2049563374</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-cfed7ef09f6ed07e9e3e4e7af8d8b6c7b5cbbe9123cd4ef317e4575565a0486f3</originalsourceid><addsrcrecordid>eNp9kctu1TAURS0EoqXwAwyQh0wSnPiRRGKCKl5SJSZlbDn2ca-vnDj40er-Dl-Ko1sqMWFiW9ba-5ytjdDbjrQd6cSHY7uqNbQ96caW8JZ07Bm67Dibmkmw_vnTm7IL9CqlIyF0IGR6iS76aeRTL8ZL9Ps24AimaMBbhEXlEgGbWO7qrweVAD8cnAcMayrRrXd4LjFl7NYclQbvi1fxXz5YnIJ3Bnu31XNfcVMxO-2hmStgzrgB7-4hnnA6pQwLfnD5gLVX-VDH4CUYZ51W2YX1NXphlU_w5vG-Qj-_fL69_tbc_Pj6_frTTaMpF7nRFswAlkxWgCEDTECBwaDsaMZZ6GHmep5h6nqqDQNLuwEYHzgXXBE2Ckuv0Puz7xbDrwIpy8WlPaNaIZQke8ImLigdWEX7M6pjSCmClVt0i4on2RG5dyOPcg8u924k4bJ2U0XvHv3LvIB5kvwtowIfzwDUlPcOokzawarBuAg6SxPc__z_APfPplE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2049563374</pqid></control><display><type>article</type><title>To reduce premature drug release while ensuring burst intracellular drug release of solid lipid nanoparticle-based drug delivery system with clathrin modification</title><source>ScienceDirect Journals</source><creator>Li, Jingcao ; Sun, Lan ; Liu, Yan ; Yao, Hongjuan ; Jiang, Shuang ; YunzhuPu ; Li, Yajuan ; Zhang, Yingge</creator><creatorcontrib>Li, Jingcao ; Sun, Lan ; Liu, Yan ; Yao, Hongjuan ; Jiang, Shuang ; YunzhuPu ; Li, Yajuan ; Zhang, Yingge</creatorcontrib><description>Nanoscale drug delivery system (NDDS) with slow premature drug release (PDR) while ensuring burst intracellular drug release (BIDR) is becoming a hot point in NDDS-based nanomedicine. Here we used clathrin to modify a solid lipid nanoparticle (SLN)-based NDDS of salinomycin (SLN-SAL) to prepare NDDS with reduced PDR while ensuring BIDR. Drug-release-kinetic experiments revealed that clathrin modified SLN-SAL (CMSLN-SAL) reduced PDR while ensured BIDR of its prototype NDDS, SLN-SAL. Mechanism experiments revealed that clathrin modification reduced PDR of SLN-SAL through increasing the mechanical strength of SLN-SAL and ensured BIDR of SLN-SAL through lipid membrane fusion after its clathrin shell was de-polymerized by a cytoplasm enzyme, HSC70. In addition, CMSLN-SAL had significantly higher intracellular uptake and stronger inhibitive effects on cancer cells than that of SLN-SAL. These results demonstrated that clathrin modification is an effective way to reduce PDR while ensuring BIDR and increasing the anticancer effects of SLN-based NDDS. The clathrin-shell of clathrin-modified solid lipid nanoparticle-based nanoscale drug delivery system of salinomycin (CMSLN-SAL) works as a cable net to resist internal osmotic pressure to block particle expending and as a cage-like scaffold to resist external pressure exerted by the blood flow at the artery bifurcation and the mouth piece of vascular clefts to block particle deformation, and thereby to reduce the drug loss in transportation, namely, the premature drug release. In tumor cells, the clathrin shell of CMSLN-SAL is depolymerized by HSC70 and the inner SLN-SAL is freed in cytosol to ensure the intracellular burst drug release. [Display omitted]</description><identifier>ISSN: 1549-9634</identifier><identifier>EISSN: 1549-9642</identifier><identifier>DOI: 10.1016/j.nano.2018.05.014</identifier><identifier>PMID: 29859268</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Clathrin ; Intracellular drug delivery ; Mechanical strength ; Nanoscale drug delivery system ; Salinomycin</subject><ispartof>Nanomedicine, 2019-01, Vol.15 (1), p.108-118</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-cfed7ef09f6ed07e9e3e4e7af8d8b6c7b5cbbe9123cd4ef317e4575565a0486f3</citedby><cites>FETCH-LOGICAL-c356t-cfed7ef09f6ed07e9e3e4e7af8d8b6c7b5cbbe9123cd4ef317e4575565a0486f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29859268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Jingcao</creatorcontrib><creatorcontrib>Sun, Lan</creatorcontrib><creatorcontrib>Liu, Yan</creatorcontrib><creatorcontrib>Yao, Hongjuan</creatorcontrib><creatorcontrib>Jiang, Shuang</creatorcontrib><creatorcontrib>YunzhuPu</creatorcontrib><creatorcontrib>Li, Yajuan</creatorcontrib><creatorcontrib>Zhang, Yingge</creatorcontrib><title>To reduce premature drug release while ensuring burst intracellular drug release of solid lipid nanoparticle-based drug delivery system with clathrin modification</title><title>Nanomedicine</title><addtitle>Nanomedicine</addtitle><description>Nanoscale drug delivery system (NDDS) with slow premature drug release (PDR) while ensuring burst intracellular drug release (BIDR) is becoming a hot point in NDDS-based nanomedicine. Here we used clathrin to modify a solid lipid nanoparticle (SLN)-based NDDS of salinomycin (SLN-SAL) to prepare NDDS with reduced PDR while ensuring BIDR. Drug-release-kinetic experiments revealed that clathrin modified SLN-SAL (CMSLN-SAL) reduced PDR while ensured BIDR of its prototype NDDS, SLN-SAL. Mechanism experiments revealed that clathrin modification reduced PDR of SLN-SAL through increasing the mechanical strength of SLN-SAL and ensured BIDR of SLN-SAL through lipid membrane fusion after its clathrin shell was de-polymerized by a cytoplasm enzyme, HSC70. In addition, CMSLN-SAL had significantly higher intracellular uptake and stronger inhibitive effects on cancer cells than that of SLN-SAL. These results demonstrated that clathrin modification is an effective way to reduce PDR while ensuring BIDR and increasing the anticancer effects of SLN-based NDDS. The clathrin-shell of clathrin-modified solid lipid nanoparticle-based nanoscale drug delivery system of salinomycin (CMSLN-SAL) works as a cable net to resist internal osmotic pressure to block particle expending and as a cage-like scaffold to resist external pressure exerted by the blood flow at the artery bifurcation and the mouth piece of vascular clefts to block particle deformation, and thereby to reduce the drug loss in transportation, namely, the premature drug release. In tumor cells, the clathrin shell of CMSLN-SAL is depolymerized by HSC70 and the inner SLN-SAL is freed in cytosol to ensure the intracellular burst drug release. [Display omitted]</description><subject>Clathrin</subject><subject>Intracellular drug delivery</subject><subject>Mechanical strength</subject><subject>Nanoscale drug delivery system</subject><subject>Salinomycin</subject><issn>1549-9634</issn><issn>1549-9642</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kctu1TAURS0EoqXwAwyQh0wSnPiRRGKCKl5SJSZlbDn2ca-vnDj40er-Dl-Ko1sqMWFiW9ba-5ytjdDbjrQd6cSHY7uqNbQ96caW8JZ07Bm67Dibmkmw_vnTm7IL9CqlIyF0IGR6iS76aeRTL8ZL9Ps24AimaMBbhEXlEgGbWO7qrweVAD8cnAcMayrRrXd4LjFl7NYclQbvi1fxXz5YnIJ3Bnu31XNfcVMxO-2hmStgzrgB7-4hnnA6pQwLfnD5gLVX-VDH4CUYZ51W2YX1NXphlU_w5vG-Qj-_fL69_tbc_Pj6_frTTaMpF7nRFswAlkxWgCEDTECBwaDsaMZZ6GHmep5h6nqqDQNLuwEYHzgXXBE2Ckuv0Puz7xbDrwIpy8WlPaNaIZQke8ImLigdWEX7M6pjSCmClVt0i4on2RG5dyOPcg8u924k4bJ2U0XvHv3LvIB5kvwtowIfzwDUlPcOokzawarBuAg6SxPc__z_APfPplE</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Li, Jingcao</creator><creator>Sun, Lan</creator><creator>Liu, Yan</creator><creator>Yao, Hongjuan</creator><creator>Jiang, Shuang</creator><creator>YunzhuPu</creator><creator>Li, Yajuan</creator><creator>Zhang, Yingge</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201901</creationdate><title>To reduce premature drug release while ensuring burst intracellular drug release of solid lipid nanoparticle-based drug delivery system with clathrin modification</title><author>Li, Jingcao ; Sun, Lan ; Liu, Yan ; Yao, Hongjuan ; Jiang, Shuang ; YunzhuPu ; Li, Yajuan ; Zhang, Yingge</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-cfed7ef09f6ed07e9e3e4e7af8d8b6c7b5cbbe9123cd4ef317e4575565a0486f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Clathrin</topic><topic>Intracellular drug delivery</topic><topic>Mechanical strength</topic><topic>Nanoscale drug delivery system</topic><topic>Salinomycin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jingcao</creatorcontrib><creatorcontrib>Sun, Lan</creatorcontrib><creatorcontrib>Liu, Yan</creatorcontrib><creatorcontrib>Yao, Hongjuan</creatorcontrib><creatorcontrib>Jiang, Shuang</creatorcontrib><creatorcontrib>YunzhuPu</creatorcontrib><creatorcontrib>Li, Yajuan</creatorcontrib><creatorcontrib>Zhang, Yingge</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nanomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jingcao</au><au>Sun, Lan</au><au>Liu, Yan</au><au>Yao, Hongjuan</au><au>Jiang, Shuang</au><au>YunzhuPu</au><au>Li, Yajuan</au><au>Zhang, Yingge</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>To reduce premature drug release while ensuring burst intracellular drug release of solid lipid nanoparticle-based drug delivery system with clathrin modification</atitle><jtitle>Nanomedicine</jtitle><addtitle>Nanomedicine</addtitle><date>2019-01</date><risdate>2019</risdate><volume>15</volume><issue>1</issue><spage>108</spage><epage>118</epage><pages>108-118</pages><issn>1549-9634</issn><eissn>1549-9642</eissn><abstract>Nanoscale drug delivery system (NDDS) with slow premature drug release (PDR) while ensuring burst intracellular drug release (BIDR) is becoming a hot point in NDDS-based nanomedicine. Here we used clathrin to modify a solid lipid nanoparticle (SLN)-based NDDS of salinomycin (SLN-SAL) to prepare NDDS with reduced PDR while ensuring BIDR. Drug-release-kinetic experiments revealed that clathrin modified SLN-SAL (CMSLN-SAL) reduced PDR while ensured BIDR of its prototype NDDS, SLN-SAL. Mechanism experiments revealed that clathrin modification reduced PDR of SLN-SAL through increasing the mechanical strength of SLN-SAL and ensured BIDR of SLN-SAL through lipid membrane fusion after its clathrin shell was de-polymerized by a cytoplasm enzyme, HSC70. In addition, CMSLN-SAL had significantly higher intracellular uptake and stronger inhibitive effects on cancer cells than that of SLN-SAL. These results demonstrated that clathrin modification is an effective way to reduce PDR while ensuring BIDR and increasing the anticancer effects of SLN-based NDDS. The clathrin-shell of clathrin-modified solid lipid nanoparticle-based nanoscale drug delivery system of salinomycin (CMSLN-SAL) works as a cable net to resist internal osmotic pressure to block particle expending and as a cage-like scaffold to resist external pressure exerted by the blood flow at the artery bifurcation and the mouth piece of vascular clefts to block particle deformation, and thereby to reduce the drug loss in transportation, namely, the premature drug release. In tumor cells, the clathrin shell of CMSLN-SAL is depolymerized by HSC70 and the inner SLN-SAL is freed in cytosol to ensure the intracellular burst drug release. [Display omitted]</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29859268</pmid><doi>10.1016/j.nano.2018.05.014</doi><tpages>11</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1549-9634
ispartof Nanomedicine, 2019-01, Vol.15 (1), p.108-118
issn 1549-9634
1549-9642
language eng
recordid cdi_proquest_miscellaneous_2049563374
source ScienceDirect Journals
subjects Clathrin
Intracellular drug delivery
Mechanical strength
Nanoscale drug delivery system
Salinomycin
title To reduce premature drug release while ensuring burst intracellular drug release of solid lipid nanoparticle-based drug delivery system with clathrin modification
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-16T22%3A09%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=To%20reduce%20premature%20drug%20release%20while%20ensuring%20burst%20intracellular%20drug%20release%20of%20solid%20lipid%20nanoparticle-based%20drug%20delivery%20system%20with%20clathrin%20modification&rft.jtitle=Nanomedicine&rft.au=Li,%20Jingcao&rft.date=2019-01&rft.volume=15&rft.issue=1&rft.spage=108&rft.epage=118&rft.pages=108-118&rft.issn=1549-9634&rft.eissn=1549-9642&rft_id=info:doi/10.1016/j.nano.2018.05.014&rft_dat=%3Cproquest_cross%3E2049563374%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c356t-cfed7ef09f6ed07e9e3e4e7af8d8b6c7b5cbbe9123cd4ef317e4575565a0486f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2049563374&rft_id=info:pmid/29859268&rfr_iscdi=true