Gold nanorod-assisted near-infrared stimulation of bullfrog sciatic nerve

Infrared neural stimulation (INS) is a new and developing approach for neural repair, with the advantages of being non-contact, spatially precise, and artifact-free. However, the disadvantage of infrared light is that it is difficult to stimulate deep tissue because of its weak penetrating power. Th...

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Bibliographic Details
Published in:Lasers in medical science 2018-12, Vol.33 (9), p.1907-1912
Main Authors: Mou, Zongxia, You, Mengxian, Xue, Wei
Format: Article
Language:English
Subjects:
Absorption
Action potential
Action Potentials - physiology
Animals
Dentistry
Gold
Gold - chemistry
I.R. radiation
Infrared lasers
Infrared radiation
Infrared Rays
Lasers
Medicine
Medicine & Public Health
Muscles
Nanoparticles
Nanorods
Nanotubes - chemistry
Nanotubes - ultrastructure
Nerves
Optical Devices
Optics
Original Article
Penetration depth
Photonics
Quantum Optics
Rana catesbeiana - physiology
Sciatic nerve
Sciatic Nerve - physiology
Spatial discrimination
Spatial resolution
Stimulation
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Summary:Infrared neural stimulation (INS) is a new and developing approach for neural repair, with the advantages of being non-contact, spatially precise, and artifact-free. However, the disadvantage of infrared light is that it is difficult to stimulate deep tissue because of its weak penetrating power. Therefore, this paper introduces an improved method using near-infrared laser to stimulate bullfrog sciatic nerves because of its strong penetrating power. Meanwhile, gold nanorods (Au NRs) are injected into the nerve to increase the absorption of light. The mechanism is the instantaneous temperature rise caused by the absorption of infrared light by Au NRs. The compound muscle action potential (CMAP) associated with the irradiated sciatic nerve is recorded by a multi-channel physiological signal instrument. The peak to peak amplitude (V pp ) of CMAP for sciatic nerves injected with Au NRs increases significantly compared to the CMAP for control nerves without Au NRs. These results demonstrate INS by labeling nerves with nanoparticle exhibiting latent capacity to increase the efficiency, spatial resolution, and the neural responsivity, and especially, can increase the penetration depth and reduce the requisite radiant exposure level.
ISSN:0268-8921
1435-604X
DOI:10.1007/s10103-018-2554-1