Weakly-coordinating N-oxide and carbonyl groups for metal-catalyzed C-H activation: the case of A-ring functionalization

Compounds featuring weakly-coordinating N-oxides or carbonyl groups, as for instance, quinoline N-oxide and quinonoid systems represent important structural scaffolds with potential biological activities. Due to their biological importance, significant efforts have been devoted to devise robust meth...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (54), p.7398-7411
Main Authors: da Silva Júnior, Eufrânio N, Jardim, Guilherme A M, Gomes, Roberto S, Liang, Yu-Feng, Ackermann, Lutz
Format: Article
Language:English
Subjects:
Activation
Carbonyl groups
Carbonyls
Molecular chains
Quinoline
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Summary:Compounds featuring weakly-coordinating N-oxides or carbonyl groups, as for instance, quinoline N-oxide and quinonoid systems represent important structural scaffolds with potential biological activities. Due to their biological importance, significant efforts have been devoted to devise robust methods for their step-economical preparation. Among these approaches, the C-H activation strategy has emerged as a powerful, versatile and efficient tool in molecular sciences. This feature article summarizes recent key advances in transition-metal-catalyzed C-H functionalization for A-ring functionalization of heterocyclic and quinoidal compounds by challenging weakly-coordinating entities, published prior to May 2018.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc03147a