Toll-like receptor 2, 4 and 9 polymorphisms and their association with ICU-acquired infections in Central Greece

To test the potential of four common Toll-like receptor (TLR) polymorphisms to predispose to specific intensive care unit (ICU)-acquired infections and affect outcomes in a Greek ICU. The incidence of TLR2-Arg753Gln, TLR4-Asp299Gly, TLR4-Thr399Ile and TLR9-T1237C polymorphisms, and their association...

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Bibliographic Details
Published in:Journal of critical care 2018-10, Vol.47, p.1-8
Main Authors: Chatzi, Maria, Papanikolaou, John, Makris, Demosthenes, Papathanasiou, Ioanna, Tsezou, Aspasia, Karvouniaris, Marios, Zakynthinos, Epaminondas
Format: Article
Language:English
Subjects:
Critical care
Cytokines
Fever
Genotype & phenotype
Greece
ICU-acquired infections
Mortality
Multi-drug resistant
Multiple organ dysfunction syndrome
Mutation
Nosocomial infections
Patients
Pneumonia
Sepsis
Septic shock
Single nucleotide polymorphisms
Staphylococcus infections
Surgical site infections
Toll-like receptors
Urinary tract infections
Urine
Ventilators
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Summary:To test the potential of four common Toll-like receptor (TLR) polymorphisms to predispose to specific intensive care unit (ICU)-acquired infections and affect outcomes in a Greek ICU. The incidence of TLR2-Arg753Gln, TLR4-Asp299Gly, TLR4-Thr399Ile and TLR9-T1237C polymorphisms, and their association with ICU-acquired infections and patients' clinical outcomes were prospectively evaluated The examined genetic polymorphisms were assessed by real-time Polymerase-Chain-Reaction (PCR). During a 15-month period, 224 patients were enrolled and genotyped. The prevalence of genetic polymorphisms for TLR4-Asp299Gly, TLR4-Thr399Ile, mixed TLR4-Asp299Gly/Thr399Ile, TLR9-T1237C and TLR2-Arg753Gln was 14.4%, 14.7%, 11.2%, 24.5% and 2.2%, respectively. TLR4 polymorphisms were associated with increased susceptibility towards specific ICU-acquired infections, i.e. Gram-negative central-nervous-system infections (CNSI), ventilator-associated pneumonia (VAP) and urinary-tract infections (UTI), principally due to multi-drug resistant (MDR) Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumonia, respectively (all P 
ISSN:0883-9441
1557-8615
DOI:10.1016/j.jcrc.2018.05.012