Magterpenoids A–C, Three Polycyclic Meroterpenoids with PTP1B Inhibitory Activity from the Bark of Magnolia officinalis var. biloba

Magterpenoid A (1), possessing a rare 4,6,11-trioxatricyclo­[5.3.1.01,5]­undecane framework with an irregular monoterpenoid moiety, magterpenoid B (2), with an unprecedented 6/6/6/6 polycyclic skeleton, and magterpenoid C (3), a novel terpenoid quinone with a C6–C3 unit, were isolated from the bark...

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Bibliographic Details
Published in:Organic letters 2018-06, Vol.20 (12), p.3682-3686
Main Authors: Li, Chuan, Li, Chuang-Jun, Ma, Jie, Chen, Fang-You, Li, Li, Wang, Xiao-Liang, Ye, Fei, Zhang, Dong-Ming
Format: Article
Language:English
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Summary:Magterpenoid A (1), possessing a rare 4,6,11-trioxatricyclo­[5.3.1.01,5]­undecane framework with an irregular monoterpenoid moiety, magterpenoid B (2), with an unprecedented 6/6/6/6 polycyclic skeleton, and magterpenoid C (3), a novel terpenoid quinone with a C6–C3 unit, were isolated from the bark of Magnolia officinalis var. biloba. Plausible biogenetic pathways of 1-3 are presented. Compounds 1 and 3 exhibited significant PTP1B inhibitory activities with IC50 values of 1.44 and 0.81 μM, respectively.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b01476