Dose‐response study for the highly aggressive and metastatic primary F3II mammary carcinoma under direct current

Electrochemical treatment has been suggested as an effective alternative to local cancer therapy. Nevertheless, its effectiveness decreases when highly aggressive primary tumors are treated. The aim of this research was to understand the growth kinetics of the highly aggressive and metastatic primar...

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Bibliographic Details
Published in:Bioelectromagnetics 2018-09, Vol.39 (6), p.460-475
Main Authors: González, Maraelys M., Morales, Dasha F., Cabrales, Luis E. B., Pérez, Daniel J., Montijano, Juan I., Castañeda, Antonio R. S., González, Victoriano G. S., Posada, Oscar O., Martínez, Janet A., Delgado, Arlem G., Martínez, Karina G., Mon, Mayrel L., Monzón, Kalet L., Ciria, Héctor M. C., Beatón, Emilia O., Brooks, Soraida C. A., González, Tamara R., Jarque, Manuel V., Mateus, Miguel A. Ó., Rodríguez, Jorge L. G., Calzado, Enaide M.
Format: Article
Language:English
Subjects:
Breast cancer
Carcinoma
Chemical treatment
Direct current
electrochemical treatment
Electrochemistry
Females
Growth kinetics
Kinetics
Males
Mammary gland
Metastases
Metastasis
modified Gompertz equation
primary F3II mammary carcinoma
Remission
Tumors
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Summary:Electrochemical treatment has been suggested as an effective alternative to local cancer therapy. Nevertheless, its effectiveness decreases when highly aggressive primary tumors are treated. The aim of this research was to understand the growth kinetics of the highly aggressive and metastatic primary F3II tumor growing in male and female BALB/c/Cenp mice under electrochemical treatment. Different amounts of electric charge (6, 9, and 18 C) were used. Two electrodes were inserted into the base, perpendicular to the tumor's long axis, keeping about 1 cm distance between them. Results have shown that the F3II tumor is highly sensitive to direct current. The overall effectiveness (complete response + partial response) of this physical agent was ≥75.0% and observed in 59.3% (16/27) of treated F3II tumors. Complete remission of treated tumors was observed in 22.2% (6/27). An unexpected result was the death of 11 direct current‐treated animals (eight females and three males). It is concluded that direct current may be addressed to significantly affect highly aggressive and metastatic primary tumor growth kinetics, including the tumor complete response. Bioelectromagnetics. 39:460–475, 2018. © 2018 Wiley Periodicals, Inc.
ISSN:0197-8462
1521-186X
DOI:10.1002/bem.22132