Well-Defined Lactose-Containing Polymer Grafted onto Silica Particles

Reversible addition-fragmentation chain transfer (RAFT) polymerization of 2-O-meth-acryloyloxyethoxyl-(2,3,4,6-tetra-O-acetyl-beta2-D- galactopyranosyl)-(1-4)-2,3,6-tri-O-acetyl-beta2-D-glucopyranoside (MAEL) was performed directly in CHCl sub(3) solutions using cumyl dithiobenzoate (CDB) as the cha...

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Bibliographic Details
Published in:Biomacromolecules 2006-01, Vol.7 (4), p.1196-1202
Main Authors: Guo, Tian-Ying, Liu, Ping, Zhu, Jing-Wei, Song, Mou-Dao, Zhang, Bang-Hua
Format: Article
Language:English
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Summary:Reversible addition-fragmentation chain transfer (RAFT) polymerization of 2-O-meth-acryloyloxyethoxyl-(2,3,4,6-tetra-O-acetyl-beta2-D- galactopyranosyl)-(1-4)-2,3,6-tri-O-acetyl-beta2-D-glucopyranoside (MAEL) was performed directly in CHCl sub(3) solutions using cumyl dithiobenzoate (CDB) as the chain transfer agent to give well-defined glycopolymers. The chemical composition and structure of the glycopolymer were characterized by super(1)HNMR, FTIR, and SEC. The living glycopolymer chains were subsequently grafted onto gamma-methacryloxypropyl-trimethoxy (MPTMS) modified silica particles. The acetyl groups of the poly(MAEL) grafted onto the silica gel particles were converted to the hydroxyl groups with CH sub(3)ONa/CH sub(3)OH, thus obtaining silica gel particles modified with well-defined lactose- carrying polymer.
ISSN:1525-7797
1526-4602
DOI:10.1021/bm051011tPII:S1525-7797(05)01011-1