Ytterbium and silver co-catalyzed synthesis of pyrrole-fused bicyclic skeletons from enynones and isocyanides

An unusual cascade reaction of isocyanide and enynone using Yb/Ag cooperative catalysis as a key step has been disclosed. The present strategy enables the double isocyanide insertion and subsequent 5- endo-dig cyclization, thus providing a quick access to structurally complex pyrrole-fused heterocyc...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (49), p.6412-6415
Main Authors: Li, Feng, Hu, Peng, Sun, Mingming, Li, Chunju, Jia, Xueshun, Li, Jian
Format: Article
Language:English
Subjects:
Cascade chemical reactions
Catalysis
Chemical synthesis
Cobalt
Silver
Ytterbium
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Summary:An unusual cascade reaction of isocyanide and enynone using Yb/Ag cooperative catalysis as a key step has been disclosed. The present strategy enables the double isocyanide insertion and subsequent 5- endo-dig cyclization, thus providing a quick access to structurally complex pyrrole-fused heterocycles. A cascade reaction of isocyanide and enynone using Yb/Ag cooperative catalysis provided a quick access to structurally complex pyrrole-fused heterocycles.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc03475c