Increased detection of human parechovirus infection in infants in England during 2016: epidemiology and clinical characteristics

BackgroundHuman parechovirus (HPeV), like enteroviruses, usually causes mild self-limiting respiratory and gastrointestinal symptoms. In infants, HPeV can occasionally cause serious illnesses, including sepsis-like syndrome and encephalitis. In summer 2016, Public Health England (PHE) received incre...

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Bibliographic Details
Published in:Archives of disease in childhood 2018-11, Vol.103 (11), p.1061-1066
Main Authors: Ferreras Antolín, Laura, Kadambari, Seilesh, Braccio, Serena, Tang, Julian Wei-Tze, Xerry, Jacqueline, Allen, David James, Ladhani, Shamez N
Format: Article
Language:English
Subjects:
Age
Anatomy
C-reactive protein
Cardiac arrhythmia
Cerebral Palsy
Cerebrospinal fluid
Cerebrospinal Fluid - virology
Departments
Early Diagnosis
Encephalitis
England - epidemiology
Enteroviruses
Epidemiology
Female
Fever
Fever - epidemiology
Fever - virology
Health surveillance
Hospitals
Humans
Illnesses
Infant
Infant, Newborn
Infants
Infections
Intensive care
Laboratories
Male
Motor Development
Neonates
Nervous system
Parechovirus - isolation & purification
Parechovirus - pathogenicity
Pediatrics
Picornaviridae Infections - diagnosis
Picornaviridae Infections - drug therapy
Picornaviridae Infections - epidemiology
Picornaviridae Infections - virology
Population Surveillance
Prospective Studies
Public health
Questionnaires
Reference Services
Respiratory diseases
Seizures
Sepsis
Sepsis - epidemiology
Sepsis - virology
Symptoms (Individual Disorders)
Viruses
Young Children
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Summary:BackgroundHuman parechovirus (HPeV), like enteroviruses, usually causes mild self-limiting respiratory and gastrointestinal symptoms. In infants, HPeV can occasionally cause serious illnesses, including sepsis-like syndrome and encephalitis. In summer 2016, Public Health England (PHE) received increasing reports of severe HPeV infections nationally. We, therefore, reviewed all infants with confirmed HPeV across England during 2016.MethodsHPeV cases in infants aged
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2017-314281