Human cathelicidin LL-37 – Does it influence the homeostatic imbalance in mental disorders?

In addition to killing pathogens and influencing immunological processes, cathelicidin LL-37 is a multifunctional host defense peptide with a role in homeostasis. It has been suggested that imbalances in homeostatic signaling from inflammatory/immune, endocrine and metabolic cascades and oxidative s...

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Bibliographic Details
Published in:Journal of biosciences 2018-06, Vol.43 (2), p.321-327
Main Authors: KOZŁOWSKA, ELŻBIETA, WYSOKIŃSKI, ADAM, MAJEWSKI, KAROL, AGIER, JUSTYNA, MARGULSKA, ALEKSANDRA, BRZEZIŃSKA-BŁASZCZYK, EWA
Format: Article
Language:English
Subjects:
Adult
Antimicrobial agents
Antimicrobial Cationic Peptides - administration & dosage
Bacteria
Biomedical and Life Sciences
Biomedicine
Bipolar disorder
Cascades
Cell Biology
Female
Homeostasis
Homeostasis - drug effects
Humans
Immunology
Inflammation
Life Sciences
Male
Mental disorders
Mental Disorders - drug therapy
Mental Disorders - genetics
Mental Disorders - physiopathology
Microbiology
Middle Aged
Oxidative stress
Oxidative Stress - drug effects
Pathogenesis
Patients
Plant Sciences
Pneumonia
Schizophrenia
Schizophrenia - drug therapy
Schizophrenia - genetics
Schizophrenia - physiopathology
Serum
Signaling
Tuberculosis
Zoology
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Summary:In addition to killing pathogens and influencing immunological processes, cathelicidin LL-37 is a multifunctional host defense peptide with a role in homeostasis. It has been suggested that imbalances in homeostatic signaling from inflammatory/immune, endocrine and metabolic cascades and oxidative stress may partially contribute to the pathogenesis of mental disorders. The purpose of the study was to identify any differences in LL-37 levels between patients with schizophrenia, euthymic bipolar disorder, bacterial pneumonia, pulmonary tuberculosis, and healthy controls. Thirty-five patients with chronic paranoid schizophrenia, 40 patients with chronic, euthymic bipolar disorder, 30 patients with bacterial pneumonia, 32 patients with pulmonary tuberculosis, and 38 healthy volunteers were included in this study. The patients with schizophrenia demonstrated a significantly lower level of LL-37 than those with bipolar disorder (p=0.006) and those with pulmonary TB (p
ISSN:0250-5991
0973-7138
DOI:10.1007/s12038-018-9751-8