Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis

Global proteomic analysis of post-mortem anterior temporal lobe samples from schizophrenia patients and non-schizophrenia individuals was performed using stable isotope labeling and shotgun proteomics. Our analysis resulted in the identification of 479 proteins, 37 of which showed statistically sign...

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Bibliographic Details
Published in:Journal of Neural Transmission 2009-03, Vol.116 (3), p.275-289
Main Authors: Martins-de-Souza, Daniel, Gattaz, Wagner F., Schmitt, Andrea, Rewerts, Christiane, Marangoni, Sérgio, Novello, José C., Maccarrone, Giuseppina, Turck, Christoph W., Dias-Neto, Emmanuel
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Basic Neurosciences
Biomarkers - analysis
Calcium - metabolism
Cell Proliferation
Chromatography, High Pressure Liquid
Energy Metabolism
Female
Genetics and Immunology - Original Article
Humans
Male
Mass Spectrometry - methods
Medicine
Medicine & Public Health
Middle Aged
Myelin Proteins
Myelin-Associated Glycoprotein - analysis
Myelin-Oligodendrocyte Glycoprotein
Nerve Tissue Proteins - analysis
Neurology
Neurosciences
Postmortem Changes
Protein Transport
Proteome - chemistry
Proteomics - methods
Psychiatry
Reference Values
Schizophrenia - metabolism
Signal Transduction
Temporal Lobe - chemistry
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Summary:Global proteomic analysis of post-mortem anterior temporal lobe samples from schizophrenia patients and non-schizophrenia individuals was performed using stable isotope labeling and shotgun proteomics. Our analysis resulted in the identification of 479 proteins, 37 of which showed statistically significant differential expression. Pathways affected by differential protein expression include transport, signal transduction, energy pathways, cell growth and maintenance and protein metabolism. The collection of protein alterations identified here reinforces the importance of myelin/oligodendrocyte and calcium homeostasis in schizophrenia, and reveals a number of new potential markers that may contribute to the understanding of the pathogenesis of this complex disease.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-008-0156-y