Risk of post‐operative surgical site infections after vedolizumab vs anti‐tumour necrosis factor therapy: a propensity score matching analysis in inflammatory bowel disease

• Published in: Alimentary pharmacology & therapeutics 2018-08, Vol.48 (3), p.340-346
• Main Authors: Park, K. T., Sceats, L., Dehghan, M., Trickey, A. W., Wren, A., Wong, J. J., Bensen, R., Limketkai, B. N., Keyashian, K., Kin, C.
• Format: Article
• Language: English
• Subjects: Abdominal surgery; Adult; Anti-Inflammatory Agents - therapeutic use; Antibodies, Monoclonal, Humanized - therapeutic use; Combined Modality Therapy; Complications; Corticosteroids; Digestive System Surgical Procedures - adverse effects; Digestive System Surgical Procedures - methods; Exposure; Female; Gangrene; Health risks; Humans; Immunotherapy - adverse effects; Immunotherapy - methods; Infections; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - drug therapy; Inflammatory Bowel Diseases - epidemiology; Inflammatory Bowel Diseases - surgery; Intestine; Longitudinal Studies; Male; Malnutrition; Opioids; Postoperative Period; Propensity Score; Retrospective Studies; Risk Factors; Surgery; Surgical site infections; Surgical Wound Infection - epidemiology; Surgical Wound Infection - etiology; Tumor necrosis factor; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor necrosis factor-TNF; Tumors
• ISSN: 0269-2813; 1365-2036; 1365-2036
• DOI: 10.1111/apt.14842

Summary Background Perioperative vedolizumab (VDZ) and anti‐tumour necrosis factor (TNFi) therapies are implicated in causing post‐operative complications in inflammatory bowel disease (IBD). Aim To compare the risk of surgical site infections (SSIs) between VDZ‐ and TNFi‐treated IBD patients in propensity‐matched cohorts. Methods The Optum Research Database was used to identify IBD patients who received VDZ or TNFi within 30 days prior to abdominal surgery between January 2015 and December 2016. The date of IBD‐related abdominal surgery was defined as the index date. SSIs were determined by ICD‐9/10 and CPT codes related to superficial wound infections or deep organ space infections after surgery. Propensity score 1:1 matching established comparable cohorts based on VDZ or TNFi exposure before surgery based on evidence‐based risk modifiers. Results The propensity‐matched sample included 186 patients who received pre‐operative biologic therapy (VDZ, n = 94; TNFi, n = 92). VDZ and TNFi cohorts were similar based on age, gender, IBD type, concomitant immunomodulator exposure, chronic opioid or corticosteroid therapy, Charlson Comorbidity Index and malnutrition. VDZ patients were more likely to undergo an open bowel resection with ostomy. After propensity score matching, there was no significant difference in post‐operative SSIs (TNFi 12.0% vs VDZ 14.9%, P = 0.56). Multivariable analysis indicated that malnutrition was the sole risk factor for developing SSI (OR 3.1, 95% CI 1.11‐8.71) regardless of the type of biologic exposure. Conclusion In the largest, risk‐adjusted cohort analysis to date, perioperative exposure to VDZ therapy was not associated with a significantly higher risk of developing an SSI compared to TNFi therapy.