Xylosyltransferase 1 and the GAG Attachment Site

Xylosyltransferase initiates glycosaminoglycan synthesis on the proteoglycan core protein. In this issue of Structure, Briggs and Hohenester (2018) determined the crystal structure of xylosyltransferase 1 and its structure in ternary complex with UDP-xylose donor and peptide acceptors, providing a m...

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Bibliographic Details
Published in:Structure (London) 2018-06, Vol.26 (6), p.797-799
Main Authors: Yu, Yanlei, Linhardt, Robert J.
Format: Article
Language:English
Subjects:
Glycosaminoglycans
Humans
Pentosyltransferases
Peptides
UDP Xylose-Protein Xylosyltransferase
Uridine Diphosphate Xylose
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Summary:Xylosyltransferase initiates glycosaminoglycan synthesis on the proteoglycan core protein. In this issue of Structure, Briggs and Hohenester (2018) determined the crystal structure of xylosyltransferase 1 and its structure in ternary complex with UDP-xylose donor and peptide acceptors, providing a mechanistic insight into the role of xylosyltransferase for glycosaminoglycan site selection. Xylosyltransferase initiates glycosaminoglycan synthesis on the proteoglycan core protein. In this issue of Structure, Briggs and Hohenester (2018) determined the crystal structure of xylosyltransferase 1 and its structure in ternary complex with UDP-xylose donor and peptide acceptors, providing a mechanistic insight into the role of xylosyltransferase for glycosaminoglycan site selection.
ISSN:0969-2126
1878-4186
DOI:10.1016/j.str.2018.05.011