Commentary on “Penetration of benzene, toluene and xylenes contained in gasolines through human abdominal skin in vitro”

In this commentary we refer to the new data recently published by Adami et al. [Adami, G., Larese, F., Venier, M., Barbieri, P., Lo Coco, F., Reisenhofer, E., 2006. Penetration of benzene, toluene and xylenes contained in gasolines through human abdominal skin in vitro. Toxicol. In Vitro 20, 1321–13...

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Bibliographic Details
Published in:Toxicology in vitro 2008-02, Vol.22 (1), p.275-277
Main Authors: Nies, Eberhard, Korinth, Gintautas
Format: Article
Language:English
Subjects:
Benzene
Benzene - pharmacokinetics
Benzene - toxicity
Carcinogens - pharmacokinetics
Carcinogens - toxicity
Dermal penetration rate
Humans
Leukaemia
Leukemia - chemically induced
Occupational exposure
Occupational Exposure - adverse effects
Percutaneous absorption
Permeability
Risk assessment
Risk Assessment - methods
Skin Absorption
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Summary:In this commentary we refer to the new data recently published by Adami et al. [Adami, G., Larese, F., Venier, M., Barbieri, P., Lo Coco, F., Reisenhofer, E., 2006. Penetration of benzene, toluene and xylenes contained in gasolines through human abdominal skin in vitro. Toxicol. In Vitro 20, 1321–1330], which we acknowledge as a reliable basis for the retrospective assessment of percutaneous benzene absorption at the workplace. The data from Adami et al. (2006) are supported by the literature and by a German approach for calculating the contribution of the dermal uptake of benzene to the total body burden. This knowledge is important for the judgment of leukaemia suspected to be an occupational disease.
ISSN:0887-2333
1879-3177
DOI:10.1016/j.tiv.2007.04.015