Inhibition of function of T cell subpopulations and decrease in cytokine production during subacute poisoning with various toxicants

Experiments on outbred albino rats showed that subacute intoxication with organophosphorus compounds dimethyldichlorovinyl phosphate and malathion primarily decreased functional activity of Th1 lymphocytes, immune reactions associated with these cells, and interferon-γ production compared to that of...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2008-08, Vol.146 (2), p.234-236
Main Authors: Zabrodskii, P. F, Germanchuk, V. G, Mandych, V. G
Format: Article
Language:English
Subjects:
Acrylates - poisoning
Animals
Arsenites - poisoning
Biomedical and Life Sciences
Biomedicine
Biophysics and Biochemistry
Cell Biology
cytokines
Dichlorvos - poisoning
Enzyme-Linked Immunosorbent Assay
Female
immunotoxicity
Interferon-gamma - blood
Interferon-gamma - metabolism
Interleukin-4 - blood
Interleukin-4 - metabolism
Internal Medicine
Laboratory Medicine
Malathion - poisoning
Male
Methanol - poisoning
Mustard Gas - poisoning
Nitriles - poisoning
Organophosphate Poisoning
Pathology
Rats
Sodium Compounds - poisoning
Th1 and Th2 lymphocytes
Th1 Cells - drug effects
Th1 Cells - immunology
Th1 Cells - metabolism
Th2 Cells - drug effects
Th2 Cells - immunology
Th2 Cells - metabolism
toxic substances
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Experiments on outbred albino rats showed that subacute intoxication with organophosphorus compounds dimethyldichlorovinyl phosphate and malathion primarily decreased functional activity of Th1 lymphocytes, immune reactions associated with these cells, and interferon-γ production compared to that of Th2 lymphocytes and interleukin-4 synthesis. Acrylic acid nitrile and methanol produced the opposite effect. Sulfur mustard and sodium arsenite were equally potent in reducing the function of Th1 and Th2 lymphocytes and production of cytokines.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-008-0256-6