Comparative analysis of temozolomide (TMZ) versus 1,3-bis (2-chloroethyl)-1 nitrosourea (BCNU) in newly diagnosed glioblastoma multiforme (GBM) patients

Purpose Although TMZ replaced BCNU as the standard initial chemotherapy in the treatment of GBM, no studies have been reported comparing BCNU with TMZ. We therefore did a retrospective analysis comparing these agents as initial therapy in GBM. Patients and methods Eighty-one patients with GBM in our...

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Bibliographic Details
Published in:Journal of neuro-oncology 2009-01, Vol.91 (2), p.221-225, Article 221
Main Authors: Vinjamuri, Mridula, Adumala, Rakesh R., Altaha, Ramin, Hobbs, Gerald R., Crowell, Edward B.
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Alkylating - therapeutic use
Carmustine - therapeutic use
Central Nervous System Neoplasms - therapy
Clinical Study - Patient Study
Combined Modality Therapy
Dacarbazine - analogs & derivatives
Dacarbazine - therapeutic use
Disease-Free Survival
Female
Glioblastoma - therapy
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Staging
Neurology
Oncology
Radiotherapy - methods
Retrospective Studies
Salvage Therapy - methods
Treatment Outcome
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Summary:Purpose Although TMZ replaced BCNU as the standard initial chemotherapy in the treatment of GBM, no studies have been reported comparing BCNU with TMZ. We therefore did a retrospective analysis comparing these agents as initial therapy in GBM. Patients and methods Eighty-one patients with GBM in our institution received both radiation and chemotherapy as initial treatment after surgery or biopsy; 49 receiving BCNU and 32 TMZ. These were analyzed for overall survival (OS) and progression-free survival (PFS) versus the type of chemotherapy used. The influence of salvage therapy on the outcome was investigated also. Results Median OS was superior in the TMZ versus the BCNU group (15.9 vs. 11.5 months) and the curves were judged to be significantly different by the log-rank test; P  
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-008-9702-6