Effect of SOD1 overexpression on age- and noise-related hearing loss

Reactive oxygen species (ROS) have been implicated in hearing loss associated with aging and noise exposure. Superoxide dismutases (SODs) form a first line of defense against damage mediated by the superoxide anion, the most common ROS. Absence of Cu/Zn SOD (SOD1) has been shown to potentiate hearin...

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Bibliographic Details
Published in:Free radical biology & medicine 2003-04, Vol.34 (7), p.873-880
Main Authors: Coling, Donald E, Yu, Kenneth C.Y, Somand, David, Satar, Bulent, Bai, Uma, Huang, Ting-Ting, Seidman, Michael D, Epstein, Charles J, Mhatre, Anand N, Lalwani, Anil K
Format: Article
Language:English
Subjects:
Age Factors
Aging
Animals
DNA, Mitochondrial - genetics
Free Radicals
Gene Deletion
Hearing loss
Hearing Loss - genetics
Hearing Loss, Noise-Induced - genetics
Humans
Mice
Mice, Inbred C57BL
Mice, Transgenic
Noise
Noise exposure
Oxidative Stress
Oxygen radical
Presbyacusis
Superoxide dismutase
Superoxide Dismutase - genetics
Superoxide Dismutase - metabolism
Time Factors
Tissue Distribution
Transgenic mice
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Summary:Reactive oxygen species (ROS) have been implicated in hearing loss associated with aging and noise exposure. Superoxide dismutases (SODs) form a first line of defense against damage mediated by the superoxide anion, the most common ROS. Absence of Cu/Zn SOD (SOD1) has been shown to potentiate hearing loss related to noise exposure and age. Conversely, overexpression of SOD1 may be hypothesized to afford a protection from age- and noise-related hearing loss. This hypothesis may be tested using a transgenic mouse model carrying the human SOD1 gene. Contrary to expectations, here, we report that no protection against age-related hearing loss was observed in mice up to 7 months of age or from noise-induced hearing loss when 8 week old mice were exposed to broadband noise (4–45 kHz, 110 dB for 1 h). Mitochondrial DNA deletion, an index of aging, was elevated in the acoustic nerve of transgenic mice compared to nontransgenic littermates. The results indicate the complexity of oxidative metabolism in the cochlea is greater than previously hypothesized.
ISSN:0891-5849
1873-4596
DOI:10.1016/S0891-5849(02)01439-9