Evaluation of the Rapid Polymyxin NP test for detection of colistin susceptibility in Enterobacteriaceae isolated from Thai patients

Development and evaluations of the Rapid Polymyxin NP test for detection of colistin resistance in Enterobacteriaceae have been recently reported. In this study, we evaluated the performance of the test using a larger number of Enterobacteriaceae, and a larger proportion of isolates with a colistin...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2018-10, Vol.92 (2), p.102-106
Main Authors: Yainoy, Sakda, Hiranphan, Monchanok, Phuadraksa, Thanawat, Eiamphungporn, Warawan, Tiengrim, Surapee, Thamlikitkul, Visanu
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibiotics resistance
Antimicrobial susceptibility testing
Carbapenem-resistant Enterobacteriaceae
Carbapenems - pharmacology
Colistin
Colistin - pharmacology
Drug Resistance, Bacterial
Enterobacteriaceae - drug effects
Enterobacteriaceae Infections - microbiology
Escherichia coli - drug effects
Humans
Klebsiella pneumoniae - drug effects
Microbial Sensitivity Tests
Polymyxins - pharmacology
Rapid Polymyxin NP test
Thailand
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Summary:Development and evaluations of the Rapid Polymyxin NP test for detection of colistin resistance in Enterobacteriaceae have been recently reported. In this study, we evaluated the performance of the test using a larger number of Enterobacteriaceae, and a larger proportion of isolates with a colistin MIC close to the breakpoint. Out of 339 isolates, the Rapid Polymyxin NP test detected colistin resistance in 13 isolates of Escherichia coli, 213 isolates of Klebsiella pneumoniae, 9 isolates of Enterobacter aerogenes, and 10 isolates of the other Enterobacteriaceae species. Sensitivity and specificity of the test for detecting colistin resistance were 100% and 95.9%, respectively. Positive predictive value and negative predictive value were 98.3% and 100%, respectively. •Performance of the Rapid Polymyxin NP Test was assessed.•A total of 339 clinical isolates of Enterobacteriaceae were included.•Rapid Polymyxin NP Test is accurate to detect colistin-resistant Enterobacteriaceae.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2018.05.009