Folic acid conjugated bovine serum albumin: An efficient smart and tumor targeted biomacromolecule for inhibition folate receptor positive cancer cells

This work described a folic acid conjugated delivery of chrysin-loaded bovine serum albumin nanoparticles, which could overcome the nonspecific targeting disadvantage. Chrysin (5, 7-dihydroxyflavone) is a natural flavonoid which have some significant biological effects on the processes of chemical d...

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Bibliographic Details
Published in:International journal of biological macromolecules 2018-10, Vol.117, p.1125-1132
Main Authors: Nosrati, Hamed, Abbasi, Reza, Charmi, Jalil, Rakhshbahar, Akram, Aliakbarzadeh, Faezeh, Danafar, Hossein, Davaran, Soodabeh
Format: Article
Language:English
Subjects:
Albumin
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
BSA
Calorimetry, Differential Scanning
Cancer
Cattle
Cell Line, Tumor
Chrysin
Drug Carriers - chemistry
Drug delivery
Drug Delivery Systems
Drug Liberation
Folic Acid - chemistry
Hemolysis
Humans
Macromolecular Substances - chemistry
Macromolecular Substances - pharmacology
Microscopy, Atomic Force
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Particle Size
Protein
Serum Albumin, Bovine - chemistry
Spectroscopy, Fourier Transform Infrared
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Summary:This work described a folic acid conjugated delivery of chrysin-loaded bovine serum albumin nanoparticles, which could overcome the nonspecific targeting disadvantage. Chrysin (5, 7-dihydroxyflavone) is a natural flavonoid which have some significant biological effects on the processes of chemical defense. Chrysin loaded bovine serum albumin nanoparticles (Chrysin-BSA NPs) were synthesized by a simple desolvation procedure. Afterward, folic acid (FA) was conjugated to the surface of Chrysin-BSA NPs by carbodiimide chemistry (Chrysin-BSA-FA NPs). The resultant Chrysin-BSA-FA NPs showed a spherical shape, with a hydrodynamic diameter of 97.5 ± 5.8 nm (mean ± SD) nm and a ζ-potential of −11.3 mV. The in vitro drug release study of chrysin presented a sustained and controlled release pattern. Hemolysis assay and cytotoxicity study results on HFF-2 cell line show that as prepared BSA NPs are biocompatible. Both the Chrysin-BSA NPs and Chrysin-BSA-FA NPs prompted an enhanced cancer cell cytotoxic effect in contrast to chrysin solution. These data recommended that the folate-modified chrysin -loaded vehicle, which demonstrated better biocompatibility and potential superiority, could be a suitable cancer therapy in targeting tumors in the future. [Display omitted]
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2018.06.026