Lectins as mitosis stimulating factors: Briefly reviewed

Lectins are carbohydrate binding proteins that can stimulate cell proliferation. This property makes these biomolecules capable of being used as mitogen reagents to study the interaction with lymphocytes allowing evaluation of immunomodulatory action, since B and T lymphocytes are related to humoral...

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Bibliographic Details
Published in:Life sciences (1973) 2018-08, Vol.207, p.152-157
Main Authors: Carvalho, Elba V.M.M., Oliveira, Weslley F., Coelho, Luana C.B.B., Correia, Maria T.S.
Format: Article
Language:English
Subjects:
Animals
B-Lymphocytes - cytology
Biomolecules
Carbohydrates
Cell division
Cell growth
Cell Proliferation
Colorimetry
Humans
Immunity, Humoral
Immunity, Innate
Innate immunity
Lectin
Lectins
Lectins - metabolism
Lymphocyte
Lymphocyte Activation - drug effects
Lymphocytes
Mice
Mitogens
Mitosis
Plant Lectins
Proteins
Rats
Reagents
Receptors, Antigen, T-Cell - metabolism
Signal Transduction
Spleen
Spleen - cytology
T-Lymphocytes - cytology
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Summary:Lectins are carbohydrate binding proteins that can stimulate cell proliferation. This property makes these biomolecules capable of being used as mitogen reagents to study the interaction with lymphocytes allowing evaluation of immunomodulatory action, since B and T lymphocytes are related to humoral and innate immunity, respectively. Isolated cells from spleen, which include lymphocytes, are widely applied as a model in screening lectin mitogenic capacity. This mitotic stimulus is initiated by interaction of the lectin with T-cell receptor on cell surface. This brief review article aims to explain how cell proliferation, especially lymphocytes, can be achieved through lectin induction. Additionally, this work intends to highlight the main colorimetric and radiographic techniques to encourage the scientific community in searching for new mitogenic lectins. [Display omitted]
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2018.06.003