gamma delta super(+) T Cells Involvement in Viral Immune Control of Chronic Human Herpesvirus 8 Infection

Little is known about what effector populations are associated with the control of human herpesvirus 8 (HHV-8) infection in vivo. We compared T lymphocyte subsets among HIV super(-)HHV-8 super(+) and HIV super(-)HHV-8 super(-) infected human individuals. alpha beta super(+) T cells from HHV-8-infect...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2008-03, Vol.180 (5), p.3417-3425
Main Authors: Barcy, Serge, De Rosa, Stephen C, Vieira, Jeffrey, Diem, Kurt, Ikoma, Minako, Casper, Corey, Corey, Lawrence
Format: Article
Language:English
Subjects:
Human herpesvirus 8
Human immunodeficiency virus
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Summary:Little is known about what effector populations are associated with the control of human herpesvirus 8 (HHV-8) infection in vivo. We compared T lymphocyte subsets among HIV super(-)HHV-8 super(+) and HIV super(-)HHV-8 super(-) infected human individuals. alpha beta super(+) T cells from HHV-8-infected individuals displayed a significantly higher percentage of differentiated effector cells among both CD4 super(+) and CD8 super(+) T cell subsets. HHV-8 infection was associated with significant expansion of gamma delta super(+) V delta 1 T cells expressing a differentiated effector cell phenotype in peripheral blood. In vitro stimulation of PBMC from HHV-8-infected individuals with either infectious viral particles or different HHV-8 viral proteins resulted in gamma delta V delta 1 T cell activation. In addition, gamma delta V delta 1 T cells displayed a strong reactivity against HHV-8-infected cell lines and prevented the release of infectious viral particles following the induction of lyric replication. These data indicate that gamma delta T cells play a role in both innate and adaptive T cell responses against HHV-8 in immunocompetent individuals.
ISSN:0022-1767