Molecular epidemiology of Clostridioides (Clostridium) difficile strains recovered from clinical trials in the US, Canada and Europe from 2006-2009 to 2012-2015

The prevalence of C. difficile infection (CDI) and severe CDI are influenced by the prevalence of specific C. difficile strains, which are themselves influenced by antimicrobial susceptibility determinants as well as antimicrobial usage patterns. Restriction endonuclease analysis (REA) typing and an...

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Bibliographic Details
Published in:Anaerobe 2018-10, Vol.53, p.38-42
Main Authors: Cheknis, Adam, Johnson, Stuart, Chesnel, Laurent, Petrella, Laurica, Sambol, Susan, Dale, Suzanne E., Nary, Julia, Sears, Pamela, Citron, Diane M., Goldstein, Ellie J.C., Gerding, Dale N.
Format: Article
Language:English
Subjects:
Antimicrobial resistance
Antimicrobial susceptibility
Clostridioides difficile
Clostridium difficile
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Summary:The prevalence of C. difficile infection (CDI) and severe CDI are influenced by the prevalence of specific C. difficile strains, which are themselves influenced by antimicrobial susceptibility determinants as well as antimicrobial usage patterns. Restriction endonuclease analysis (REA) typing and antimicrobial susceptibility testing were used to characterize 1808 C. difficile isolates obtained from patients enrolled in four multicenter, multi-country, randomized CDI treatment trials conducted between 2006 and 2009 and between 2012 and 2015. By 2015, the epidemic REA group BI strain (RT027) had decreased in prevalence in North America (US: 43%–18%, Canada: 39%–24%, P 
ISSN:1075-9964
1095-8274
DOI:10.1016/j.anaerobe.2018.05.009