Disseminated nontuberculous mycobacterial disease in a cat caused by Mycobacterium sp. strain MFM001

•Mycobacterium sp. strain MFM001 is a new slow-growing nontuberculous mycobacteria.•MFM001 led to disseminated mycobacterial disease in an immunocompromised cat.•Disseminated disease is characterized by transmural granulomatous gastroenterocolitis.•MFM001 was closely related to M. kyorinense or M. c...

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Bibliographic Details
Published in:Veterinary microbiology 2018-07, Vol.220, p.90-96
Main Authors: Kayanuma, Hideki, Ogihara, Kikumi, Yoshida, Shiomi, Yamamoto, Kaori, Wada, Takayuki, Yamamoto, Taro, Tsuyuki, Yuzo, Madarame, Hiroo
Format: Article
Language:English
Subjects:
Bacteria
Cat
Cats
Disseminated infection
Immunosuppression
Infections
Mycobacterium
Mycobacterium sp
rRNA 16S
Strain MFM001
Transmural granulomatous gastroenterocolitis
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Summary:•Mycobacterium sp. strain MFM001 is a new slow-growing nontuberculous mycobacteria.•MFM001 led to disseminated mycobacterial disease in an immunocompromised cat.•Disseminated disease is characterized by transmural granulomatous gastroenterocolitis.•MFM001 was closely related to M. kyorinense or M. celatum.•MFM001 was identical with an unspecified M. sp. strain B10-07.09.0206. Mycobacterium sp. strain MFM001 (MFM001), a new strain of slow-growing nontuberculous mycobacteria not associated with the Mycobacterium avium complex, led to disseminated mycobacterial disease characterized by transmural granulomatous gastroenterocolitis of lepromatous type in a cat treated with immunosuppressive medication. MFM001 was found to be closely related to M. kyorinense or M. celatum by partial sequence of 16S rDNA, and identical with an unspecified M. sp. strain B10-07.09.0206 isolated from a human pulmonary infection in Germany. MFM001 should be considered as a pathogenic organism in cats, especially in immunocompromised animals.
ISSN:0378-1135
1873-2542
DOI:10.1016/j.vetmic.2018.05.010