Calcifying Odontogenic Cyst Associated With Dentigerous Cyst in a 15-Year-Old Girl

Calcifying odontogenic cyst (COC) is a rare odontogenic cyst with ameloblastic epithelial lining containing clusters of ghost cells. COCs have been described in association with several odontogenic tumors, more commonly odontomas and rarely with dentigerous cyst (DC). In this article, we describe a...

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Bibliographic Details
Published in:International journal of surgical pathology 2018-12, Vol.26 (8), p.758-765
Main Authors: Aristizabal Arboleda, Paola, Sánchez-Romero, Celeste, de Almeida, Oslei Paes, Flores Alvarado, Sergio A., Martínez Pedraza, Ricardo
Format: Article
Language:English
Subjects:
Adolescent
Biomarkers, Tumor - analysis
Cysts
Dentigerous Cyst - complications
Dentigerous Cyst - diagnostic imaging
Dentigerous Cyst - surgery
Female
Humans
Maxilla - diagnostic imaging
Maxilla - pathology
Maxilla - surgery
Maxillary Neoplasms - diagnosis
Maxillary Neoplasms - etiology
Maxillary Neoplasms - pathology
Maxillary Neoplasms - surgery
Odontogenic Cyst, Calcifying - diagnosis
Odontogenic Cyst, Calcifying - etiology
Odontogenic Cyst, Calcifying - pathology
Odontogenic Cyst, Calcifying - surgery
Radiography, Panoramic
Tomography, X-Ray Computed
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Summary:Calcifying odontogenic cyst (COC) is a rare odontogenic cyst with ameloblastic epithelial lining containing clusters of ghost cells. COCs have been described in association with several odontogenic tumors, more commonly odontomas and rarely with dentigerous cyst (DC). In this article, we describe a case of COC associated with DC in a 15-year-old girl, who presented with a swelling on the right middle third of the face, producing facial asymmetry. Panoramic radiography showed a well-circumscribed, corticated, and unilocular radiolucency at the level of the right maxillary sinus, involving 2 unerupted premolars. The lesion was enucleated and histologically revealed a COC associated with DC, which presented mucous metaplasia. Immunohistochemical reactions were performed to better illustrate this rare synchronous occurrence of COC and DC, showing positivity for CK5, CK14, CK19, and p63 in both lesions. CK18 was negative in COC, and Bcl-2 was negative in DC. Periodic acid Schiff highlighted the mucous cells in the DC lining.
ISSN:1066-8969
1940-2465
DOI:10.1177/1066896918777639