Studies on the Biocompatibility of Poly(diethyl vinyl‐phosphonate) with a New Fluorescent Marker

Utilization of group transfer polymerization for the synthesis of poly(diethyl vinylphosphonate) (PDEVP) allows its controlled end‐group functionalization. Thus, a new fluorescent chromophore/PDEVP conjugate is prepared and subjected to biocompatibility tests on two different human cell lines. In co...

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Bibliographic Details
Published in:Macromolecular rapid communications. 2018-08, Vol.39 (15), p.e1800259-n/a
Main Authors: Schwarzenböck, Christina, Vagin, Sergei I., Heinz, Werner R., Nelson, Peter J., Rieger, Bernhard
Format: Article
Language:English
Subjects:
Biocompatibility
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Cell Line
Cell lines
Cell Survival - drug effects
Chemical synthesis
Chromophores
Dose-Response Relationship, Drug
Fluorescence
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Fluorescent Dyes - pharmacology
Fluorescent indicators
Group transfer polymerization
HEK293 Cells
Humans
Molecular Structure
Polymerization
polyvinylphosphonates
Structure-Activity Relationship
thermoresponsive polymers
water‐soluble polymers
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Summary:Utilization of group transfer polymerization for the synthesis of poly(diethyl vinylphosphonate) (PDEVP) allows its controlled end‐group functionalization. Thus, a new fluorescent chromophore/PDEVP conjugate is prepared and subjected to biocompatibility tests on two different human cell lines. In contrast to the previous studies, the tagged polymer is not absorbed by cells from the solution and has nearly no impact on cell mortality rate. Poly(diethyl vinylphosphonate) (PDEVP) tagged with a new fluorescent marker is not cytotoxic, in contrast to the pyrene‐functionalized PDEVP. Furthermore, different from the previous studies on functionalized PDEVPs, the new polymer shows no uptake by two tested human cell lines, HMEC‐1 and HEK‐293.
ISSN:1022-1336
1521-3927
DOI:10.1002/marc.201800259