Safe administration of rotavirus vaccine in a cohort of infants exposed to immunosuppressive drugs during gestation

In utero exposure to immunosuppressive drugs might be a contraindication to rotavirus vaccine, but that may vary according to the immunosuppressive regimen. We evaluated 24 infants born to kidney transplanted mothers exposed to 3 immunosuppressants during pregnancy (prednisone, azathioprine, and tac...

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Bibliographic Details
Published in:Transplant infectious disease 2018-10, Vol.20 (5), p.e12951-n/a
Main Authors: Dinelli, Maria Isabel S., dos Santos, Amélia M. N., Weckx, Lily Y., Moraes‐Pinto, Maria Isabel
Format: Article
Language:English
Subjects:
Azathioprine
Case-Control Studies
child
Cohort Studies
Cyclosporins
Exposure
Female
Follow-Up Studies
Gestation
Graft Rejection - immunology
Graft Rejection - prevention & control
Humans
Immunization Schedule
immunosuppressant
Immunosuppressive agents
Immunosuppressive Agents - adverse effects
Infant
Infants
Intrauterine exposure
Kidney transplantation
Kidney Transplantation - adverse effects
Kidneys
Maternal Exposure - adverse effects
Maternal-Fetal Exchange
Prednisone
Pregnancy
Prospective Studies
Rotavirus
Rotavirus Infections - prevention & control
rotavirus vaccine
Rotavirus Vaccines - administration & dosage
Rotavirus Vaccines - adverse effects
Tacrolimus
transplant
Vaccination
Vaccines
Vaccines, Attenuated - administration & dosage
Vaccines, Attenuated - adverse effects
Viruses
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Description
Summary:In utero exposure to immunosuppressive drugs might be a contraindication to rotavirus vaccine, but that may vary according to the immunosuppressive regimen. We evaluated 24 infants born to kidney transplanted mothers exposed to 3 immunosuppressants during pregnancy (prednisone, azathioprine, and tacrolimus or cyclosporine) and 31 control infants not exposed to these medications. No differences in adverse events were detected after rotavirus vaccination at 2 and 4 months.
ISSN:1398-2273
1399-3062
DOI:10.1111/tid.12951