Mixed amanita phalloides poisoning with rhabdomyolysis: analysis of 4 cases

We report the clinical characteristics, treatments and outcomes of 4 rare cases of mixed amanita fuliginea and amanita rimosa poisoning with rhabdomyolysis, and review the research progress in the intoxication mechanism and treatment. The latent time of amanita poisoning, defined as the period from...

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Bibliographic Details
Published in:Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2018-05, Vol.38 (5), p.635-638
Main Authors: Lu, Zhan, Chen, Yan-Bo, Huang, Bo, Peng, Sheng, Wang, Qian-Wen, Liu, Dan-Lei, Wang, Hua
Format: Article
Language:Chinese
Subjects:
Amanita
Hemofiltration
Hemoperfusion
Humans
Multiple Organ Failure - etiology
Multiple Organ Failure - prevention & control
Mushroom Poisoning - complications
Mushroom Poisoning - therapy
Rhabdomyolysis - etiology
Rhabdomyolysis - therapy
Time Factors
Treatment Outcome
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Summary:We report the clinical characteristics, treatments and outcomes of 4 rare cases of mixed amanita fuliginea and amanita rimosa poisoning with rhabdomyolysis, and review the research progress in the intoxication mechanism and treatment. The latent time of amanita poisoning, defined as the period from the ingestion of poisonous mushroom to the onset of gastrointestinal symptoms, was about 8 days, and the severity of poisoning was associated with the amount of mushroom ingested. All the 4 patients developed multiple organ dysfunctions within 3 to 4 days after mushroom ingestion, predominantly in the liver, kidney and central nervous system accompanied with acute gastrointestinal injury and rhabdomyolysis. The treatment measures included persistent hemofiltration and intermittent hemoperfusion once daily for 5-7 days, and plasma exchange was administered in 2 cases for 1 or 2 times. High-dose vitamin C, glucose and corticosteroid were also given to the patients. After the treatments, two patients were cured and th
ISSN:1673-4254