Treatment strategies for adolescent and young adult patients with acute myeloid leukemia

Adolescents and young adults (AYAs) form a unique group of patients with newly diagnosed acute myeloid leukemia (AML). They differ in terms of disease biology, psychosocial challenges, survival, and in other important respects from children as well as from middle-aged and older adults. AYAs may be t...

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Bibliographic Details
Published in:Blood 2018-07, Vol.132 (4), p.362-368
Main Authors: O'Dwyer, Kristen, Freyer, David R., Horan, John T.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Decision Making
Disease Management
Humans
Leukemia, Myeloid, Acute - pathology
Leukemia, Myeloid, Acute - therapy
Practice Guidelines as Topic - standards
Risk Factors
Young Adult
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Summary:Adolescents and young adults (AYAs) form a unique group of patients with newly diagnosed acute myeloid leukemia (AML). They differ in terms of disease biology, psychosocial challenges, survival, and in other important respects from children as well as from middle-aged and older adults. AYAs may be treated using pediatric protocols developed in trials composed primarily of younger patients, or using adult protocols developed in trials composed primarily of older patients. After reviewing the distinguishing characteristics of AYAs with AML, we compare and contrast the chemotherapy approaches and argue that neither the pediatric nor adult approaches may be ideally suited for AYAs and the development of AYA-specific approaches merits further consideration. We finish by putting forth ideas for future research to optimize chemotherapy treatment of AYAs with AML.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2017-12-778472